Structured evidence table for Probiotics Acne Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Acne Randomized Trial | Standard therapy often relies on antibiotics, but the long-term use has increased antibiotic resistance, including in Indonesia. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Acne Randomized Trial | Background Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes , which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Acne Randomized Trial | Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. | 2 | Lestari K (2026) | Oral probiotics and topical secretome to enhance clinical outcomes and microbiome restoration in acne vulgaris: a double-blind, randomised controlled trial protocol. |
| Probiotics Acne Randomized Trial | These treatments show varying degrees of efficacy and improved safety profiles, but most lack head-to-head comparisons with isotretinoin. | 4 | Tommasino N (2026) | Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. |
| Probiotics Acne Randomized Trial | Conclusion Several systemic options beyond isotretinoin have emerged, showing potential in specific subgroups or as adjunctive therapies. | 4 | Tommasino N (2026) | Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. |
| Probiotics Acne Randomized Trial | However, further large-scale comparative studies are needed to define their roles within evidence-based acne management algorithms. | 4 | Tommasino N (2026) | Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. |
| Probiotics Acne Randomized Trial | Background Acne vulgaris is a common inflammatory skin disorder with significant psychosocial impact. | 4 | Tommasino N (2026) | Beyond Isotretinoin: A Narrative Review of Emerging Systemic Therapies for Moderate-to-Severe Acne. |
Source documents