Structured evidence table for Prebiotic Gut Microbiome Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Prebiotic Gut Microbiome Randomized Trial | Background Gastrointestinal discomfort affects up to 70% of individuals with spinal cord injury (SCI), largely due to gut dysbiosis caused by altered transit time and reduced gastrointestinal motility from autonomic disruption. | 2 | Trunz J (2026) | Probiotic and Prebiotic Supplementation for Gastrointestinal Discomfort in Chronic Spinal Cord Injury (PRO-GIDSCI): A Randomized Controlled Crossover Trial Protocol. |
| Prebiotic Gut Microbiome Randomized Trial | Emerging evidence links prebiotics and probiotics to improved microbiome balance and reduced inflammation, yet data in SCI remain limited. | 2 | Trunz J (2026) | Probiotic and Prebiotic Supplementation for Gastrointestinal Discomfort in Chronic Spinal Cord Injury (PRO-GIDSCI): A Randomized Controlled Crossover Trial Protocol. |
| Prebiotic Gut Microbiome Randomized Trial | There is strong evidence of a correlation linking gut dysbiosis with reduced microbial diversity and a disruption in the balance of microbial communities, and inflammatory and metabolic disorders, including obesity and type 2 diabetes mellitus (T2DM) [,,]. | 3 | Alhaj Omar A. (2026) | Dairy Bioactive Compounds as Precision Modulators of Gut Microbiota: From Molecular Mechanisms to Personalized Immunometabolic Health |
| Prebiotic Gut Microbiome Randomized Trial | Meta-analyses of clinical interventions corroborate the results of regular yogurt or kefir intake, showing significant decreases in fasting glucose, low-density lipoprotein (LDL) cholesterol, and systemic C-reactive protein (CRP) in dysbiosis-associated conditions, with effect sizes dependent on strain composition, dose, and host genotype [,,,]. | 3 | Alhaj Omar A. (2026) | Dairy Bioactive Compounds as Precision Modulators of Gut Microbiota: From Molecular Mechanisms to Personalized Immunometabolic Health |
| Prebiotic Gut Microbiome Randomized Trial | 9 35 36 9 9 37 9 35 38 39 9 35 Figure 1 Despite the compelling evidence for the DB components as GM modulators, three critical knowledge gaps remain, including dose–response characterization, long-term clinical efficacy, and elucidation of the mechanism’s pathway [,,]. | 3 | Alhaj Omar A. (2026) | Dairy Bioactive Compounds as Precision Modulators of Gut Microbiota: From Molecular Mechanisms to Personalized Immunometabolic Health |
| Prebiotic Gut Microbiome Randomized Trial | 1 2 3 4 5 6 7 1 1 3 1 8 1 9 10 1 9 11 12 1 10 13 9 14 The GM is the complex community of Archaea, Bacteria, Eukarya, and viruses that live in the gastrointestinal tract in an intimate unit between the host and the microbes, called the holobiont [,]. | 3 | Alhaj Omar A. (2026) | Dairy Bioactive Compounds as Precision Modulators of Gut Microbiota: From Molecular Mechanisms to Personalized Immunometabolic Health |
| Prebiotic Gut Microbiome Randomized Trial | The rise in obesity has increased the prevalence of metabolic OA, underscoring the need for effective management to delay or prevent knee replacement. | 4 | Wang W (2026) | Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis. |
| Prebiotic Gut Microbiome Randomized Trial | By reshaping the composition and function of the gut microbiota, prebiotics increased diet-derived carbohydrate availability, mitigated excessive host-glycan degradation and mucosal barrier disruption, reduced systemic inflammation and metabolic dysregulation, ultimately enhancing metabolic health and improving physical performance. | 4 | Wang W (2026) | Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis. |
| Prebiotic Gut Microbiome Randomized Trial | In a diet-induced obese rat model, prebiotics reduced tibial cartilage degeneration and synovial membrane thickening, conferring protection against OA onset and progression through a common inflammatory pathway. | 4 | Wang W (2026) | Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis. |
| Prebiotic Gut Microbiome Randomized Trial | Knee osteoarthritis (OA) is a prevalent, painful, degenerative disease lacking effective disease-modifying drugs. | 4 | Wang W (2026) | Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis. |
Source documents