topicPostbiotics Gut Health Randomized Trial
claimHowever, most mechanistic data derive from rodent models; human evidence remains largely correlational and cross-sectional.
evidence level3
citationWang R (2026)
sourceLachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.
topicPostbiotics Gut Health Randomized Trial
claimWe conclude that although Lachnospiraceae hold promise for immunomodulatory functional foods, current evidence does not support clinical or commercial claims.
evidence level3
citationWang R (2026)
sourceLachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.
topicPostbiotics Gut Health Randomized Trial
claimThe interplay between diet, gut microbiota, and host immunity is central to food science.
evidence level3
citationWang R (2026)
sourceLachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.
topicPostbiotics Gut Health Randomized Trial
claimThe Lachnospiraceae family ferments dietary fibers to produce short-chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential.
evidence level3
citationWang R (2026)
sourceLachnospiraceae in the Food-Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers.
topicPostbiotics Gut Health Randomized Trial
claimThe gut-immune-metabolic axis has emerged as a central regulator of human health, with growing evidence indicating that microbiota-derived metabolites improve gut microbial ecology, enhance intestinal barrier integrity, reduce systemic inflammation, and maintain metabolic homeostasis.
evidence level4
citationAbbas A (2026)
sourcePostbiotics as Next Generation Biotherapeutics Targeting the Gut-Immune-Metabolic Axis: An Integrative Review.
topicPostbiotics Gut Health Randomized Trial
claimThis review synthesizes current mechanistic and clinical evidence on the role of postbiotics in regulating intestinal barrier integrity, immune responses, oxidative stress, and metabolic-endocrine homeostasis.
evidence level4
citationAbbas A (2026)
sourcePostbiotics as Next Generation Biotherapeutics Targeting the Gut-Immune-Metabolic Axis: An Integrative Review.
topicPostbiotics Gut Health Randomized Trial
claimThe literature was identified through the PubMed/MEDLINE, Scopus, and Web of Science, integrating evidence from experimental, mechanistic, animal and clinical studies on the therapeutic potential of postbiotics to modulate the gut-immune-metabolic axis.
evidence level4
citationAbbas A (2026)
sourcePostbiotics as Next Generation Biotherapeutics Targeting the Gut-Immune-Metabolic Axis: An Integrative Review.