Structured evidence table for Postbiotic Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Postbiotic Sleep Randomized Trial | Compared with placebo, SNK improved Sleepiness on Rising ( p = 0.032) and Initiation and Maintenance of Sleep ( p = 0.010). | 2 | Watanabe T (2025) | Effect of Heat-Killed <i>Lactiplantibacillus plantarum</i> SNK12 on Sleep Quality and Stress-Related Neuroendocrine and Inflammatory Biomarkers in Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. |
| Postbiotic Sleep Randomized Trial | Heat-killed Lactiplantibacillus plantarum SNK12 (SNK), isolated from a traditional Japanese fermented food, has been suggested to influence sleep quality, but human data on sleep improvement with heat-killed lactic acid bacteria (postbiotics) remain limited. | 2 | Watanabe T (2025) | Effect of Heat-Killed <i>Lactiplantibacillus plantarum</i> SNK12 on Sleep Quality and Stress-Related Neuroendocrine and Inflammatory Biomarkers in Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. |
| Postbiotic Sleep Randomized Trial | We conducted a randomized controlled trial to test whether heat-killed SNK (≥1 × 10 11 cells/day for 4 weeks) improves sleep quality and alters stress-related immune and neuroendocrine biomarkers. | 2 | Watanabe T (2025) | Effect of Heat-Killed <i>Lactiplantibacillus plantarum</i> SNK12 on Sleep Quality and Stress-Related Neuroendocrine and Inflammatory Biomarkers in Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial. |
| Postbiotic Sleep Randomized Trial | [1] [2] According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), specific criteria must be met to diagnose insomnia, including: (a) Dissatisfaction with sleep duration or quality, including difficulty falling asleep, prolonged sleep, and early awakening, accompanied by associated symptoms. | 3 | Wu Qiong (2026) | Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions |
| Postbiotic Sleep Randomized Trial | Gaining a comprehensive understanding of the neural circuits associated with various chemicals involved in sleep-wake transition is crucial for advancing strategies for managing insomnia. | 3 | Wu Qiong (2026) | Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions |
| Postbiotic Sleep Randomized Trial | Table 1 Table 1 Sleep regulation factors Receptors Primary sources Findings Melatonin (Mel) 1 2 MTMT Pineal gland 1 2 1 1 [31] [31] [32] [33] [34] [35] [36] [37] MTis associated with the regulation of circadian rhythms and primarily involved in the modulation of REM sleep, whereas selectively promoting NREM sleep.MTincreases non-rapid eye movement (NREM) sleep, while MTregulates rapid eye movement (REM) sleep. | 3 | Wu Qiong (2026) | Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions |
| Postbiotic Sleep Randomized Trial | (b) The sleep disturbance causes clinically significant distress or impairment in social, occupational, educational, academic, behavioral or other important areas of functioning. | 3 | Wu Qiong (2026) | Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions |
Source documents