evidence table

Pomegranate Menopausal Symptoms Randomized Trial Evidence Table

Structured evidence table for Pomegranate Menopausal Symptoms Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Pomegranate Menopausal Symptoms Randomized TrialThey not only have a significant impact on quality of life and social well-being [,,] but, if left untreated or undertreated, they can increase the risk of developing various complications, including organ dysfunction [,] and genitourinary cancers [,,].1Piragine Eugenia (2026)Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
Pomegranate Menopausal Symptoms Randomized TrialAmong these, polyphenols, which can be found in plants [] but also in microbial sources such as algae [], have been extensively studied in both preclinical and clinical settings [,,,,,,,,,,,].1Piragine Eugenia (2026)Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
Pomegranate Menopausal Symptoms Randomized TrialThese effects may be at least partly attributed to the ability of natural ITCs to slowly release hydrogen sulfide (HS), a gasotransmitter with health-promoting properties [,,], whose biosynthesis is reduced during aging or under disease conditions [].1Piragine Eugenia (2026)Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
Pomegranate Menopausal Symptoms Randomized Trial1 2 3 4 4 Genitourinary pathological conditions represent a growing global health threat, posing significant challenges not only for affected individuals, but also for caregivers and healthcare professionals [,,].1Piragine Eugenia (2026)Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
Pomegranate Menopausal Symptoms Randomized TrialBackground/Objectives : Interindividual variability in polyphenol metabolism may help explain the inconsistent effects of polyphenol intake on health outcomes.2Jarrín-Orozco MP (2025)Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.
Pomegranate Menopausal Symptoms Randomized TrialThis study compared, for the first time, (i) polyphenol-related gut microbiota metabotypes (urolithins: UM0, UMA, UMB; equol: EP, ENP; lunularin: LP, LNP) and their clusters (MCs) in non-medicated premenopausal (Pre-M) and postmenopausal (Post-M) women and (ii) the impact of an 8-week intake of a polyphenol-rich plant extract mixture (PPs) on the quality of life (QoL) of Post-M.2Jarrín-Orozco MP (2025)Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.
topicPomegranate Menopausal Symptoms Randomized Trial
claimThey not only have a significant impact on quality of life and social well-being [,,] but, if left untreated or undertreated, they can increase the risk of developing various complications, including organ dysfunction [,] and genitourinary cancers [,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicPomegranate Menopausal Symptoms Randomized Trial
claimAmong these, polyphenols, which can be found in plants [] but also in microbial sources such as algae [], have been extensively studied in both preclinical and clinical settings [,,,,,,,,,,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicPomegranate Menopausal Symptoms Randomized Trial
claimThese effects may be at least partly attributed to the ability of natural ITCs to slowly release hydrogen sulfide (HS), a gasotransmitter with health-promoting properties [,,], whose biosynthesis is reduced during aging or under disease conditions [].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicPomegranate Menopausal Symptoms Randomized Trial
claim1 2 3 4 4 Genitourinary pathological conditions represent a growing global health threat, posing significant challenges not only for affected individuals, but also for caregivers and healthcare professionals [,,].
evidence level1
citationPiragine Eugenia (2026)
sourcePotential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
topicPomegranate Menopausal Symptoms Randomized Trial
claimBackground/Objectives : Interindividual variability in polyphenol metabolism may help explain the inconsistent effects of polyphenol intake on health outcomes.
evidence level2
citationJarrín-Orozco MP (2025)
sourcePolyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.
topicPomegranate Menopausal Symptoms Randomized Trial
claimThis study compared, for the first time, (i) polyphenol-related gut microbiota metabotypes (urolithins: UM0, UMA, UMB; equol: EP, ENP; lunularin: LP, LNP) and their clusters (MCs) in non-medicated premenopausal (Pre-M) and postmenopausal (Post-M) women and (ii) the impact of an 8-week intake of a polyphenol-rich plant extract mixture (PPs) on the quality of life (QoL) of Post-M.
evidence level2
citationJarrín-Orozco MP (2025)
sourcePolyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.

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Source documents

  1. Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies
  2. Polyphenol-Related Gut Metabotype Signatures Linked to Quality of Life in Postmenopausal Women: A Randomized, Placebo-Controlled Crossover Trial.