Pomegranate Cardiovascular Randomized Trial Evidence Table

Structured evidence table for Pomegranate Cardiovascular Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Pomegranate Cardiovascular Randomized TrialResults PJ consumption was associated with significant reductions in TG (MD: -8.2 mg/dL) and LDL-C (MD: -4.8 mg/dL), and a significant increase in HDL-C (MD: +2.8 mg/dL).1Ghaemi F (2026)Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
Pomegranate Cardiovascular Randomized TrialConclusion PJ may improve lipid profiles, particularly by reducing TG and LDL-C and increasing HDL-C levels.1Ghaemi F (2026)Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
Pomegranate Cardiovascular Randomized TrialObjective Pomegranate juice (PJ) is rich in polyphenols with potential lipid-lowering effects.1Ghaemi F (2026)Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
Pomegranate Cardiovascular Randomized TrialThis study aimed to evaluate the impact of PJ consumption on blood lipid parameters through a systematic review and meta-analysis of randomized controlled trials (RCTs).1Ghaemi F (2026)Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
Pomegranate Cardiovascular Randomized TrialConclusion Under tightly controlled dietary conditions, a single dose of pomegranate extract did not reduce post-OCC TMAO responses in the overall cohort.2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
Pomegranate Cardiovascular Randomized TrialIntroduction Polyphenol-rich pomegranate extract has been shown to inhibit microbial trimethylamine (TMA) production from L-carnitine.2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
Pomegranate Cardiovascular Randomized TrialPrevious clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC).2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Cardiovascular Randomized Trial
claimResults PJ consumption was associated with significant reductions in TG (MD: -8.2 mg/dL) and LDL-C (MD: -4.8 mg/dL), and a significant increase in HDL-C (MD: +2.8 mg/dL).
evidence level1
citationGhaemi F (2026)
sourcePomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
topicPomegranate Cardiovascular Randomized Trial
claimConclusion PJ may improve lipid profiles, particularly by reducing TG and LDL-C and increasing HDL-C levels.
evidence level1
citationGhaemi F (2026)
sourcePomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
topicPomegranate Cardiovascular Randomized Trial
claimObjective Pomegranate juice (PJ) is rich in polyphenols with potential lipid-lowering effects.
evidence level1
citationGhaemi F (2026)
sourcePomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
topicPomegranate Cardiovascular Randomized Trial
claimThis study aimed to evaluate the impact of PJ consumption on blood lipid parameters through a systematic review and meta-analysis of randomized controlled trials (RCTs).
evidence level1
citationGhaemi F (2026)
sourcePomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
topicPomegranate Cardiovascular Randomized Trial
claimConclusion Under tightly controlled dietary conditions, a single dose of pomegranate extract did not reduce post-OCC TMAO responses in the overall cohort.
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Cardiovascular Randomized Trial
claimIntroduction Polyphenol-rich pomegranate extract has been shown to inhibit microbial trimethylamine (TMA) production from L-carnitine.
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Cardiovascular Randomized Trial
claimPrevious clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC).
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.

Source documents

  1. Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
  2. Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.