evidence table

Pomegranate Blood Flow Randomized Trial Evidence Table

Structured evidence table for Pomegranate Blood Flow Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Pomegranate Blood Flow Randomized TrialConclusion Under tightly controlled dietary conditions, a single dose of pomegranate extract did not reduce post-OCC TMAO responses in the overall cohort.2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
Pomegranate Blood Flow Randomized TrialIntroduction Polyphenol-rich pomegranate extract has been shown to inhibit microbial trimethylamine (TMA) production from L-carnitine.2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
Pomegranate Blood Flow Randomized TrialPrevious clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC).2Haarhuis JE (2026)Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
Pomegranate Blood Flow Randomized TrialPSO significantly reduced histological injury: Median total injury score was 9 (7-11) in IR, 6 (4-8) in IR + PSO low, and 3 (2-5) in IR + PSO high ( P < 0.001).4Altimimi MLM (2026)Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
Pomegranate Blood Flow Randomized TrialMultivariable logistic regression showed that PSO treatment was associated with lower odds of severe IR injury (odds ratio: 0.40, 95% confidence interval: 0.18-0.90).4Altimimi MLM (2026)Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
Pomegranate Blood Flow Randomized TrialIn this exploratory study, PSO supplementation was associated with reduced histological and biochemical markers of IR injury, with greater effects at higher dose.4Altimimi MLM (2026)Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
Pomegranate Blood Flow Randomized TrialLower-extremity ischemia-reperfusion (IR) injury causes oxidative stress, inflammation, and cell death.4Altimimi MLM (2026)Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
topicPomegranate Blood Flow Randomized Trial
claimConclusion Under tightly controlled dietary conditions, a single dose of pomegranate extract did not reduce post-OCC TMAO responses in the overall cohort.
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Blood Flow Randomized Trial
claimIntroduction Polyphenol-rich pomegranate extract has been shown to inhibit microbial trimethylamine (TMA) production from L-carnitine.
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Blood Flow Randomized Trial
claimPrevious clinical studies have examined effects of polyphenol-rich interventions on fasting trimethylamine N-oxide (TMAO) concentrations but have not assessed pharmacokinetic TMAO responses following an oral carnitine challenge (OCC).
evidence level2
citationHaarhuis JE (2026)
sourceEffect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
topicPomegranate Blood Flow Randomized Trial
claimPSO significantly reduced histological injury: Median total injury score was 9 (7-11) in IR, 6 (4-8) in IR + PSO low, and 3 (2-5) in IR + PSO high ( P < 0.001).
evidence level4
citationAltimimi MLM (2026)
sourceEffects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
topicPomegranate Blood Flow Randomized Trial
claimMultivariable logistic regression showed that PSO treatment was associated with lower odds of severe IR injury (odds ratio: 0.40, 95% confidence interval: 0.18-0.90).
evidence level4
citationAltimimi MLM (2026)
sourceEffects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
topicPomegranate Blood Flow Randomized Trial
claimIn this exploratory study, PSO supplementation was associated with reduced histological and biochemical markers of IR injury, with greater effects at higher dose.
evidence level4
citationAltimimi MLM (2026)
sourceEffects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.
topicPomegranate Blood Flow Randomized Trial
claimLower-extremity ischemia-reperfusion (IR) injury causes oxidative stress, inflammation, and cell death.
evidence level4
citationAltimimi MLM (2026)
sourceEffects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.

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Source documents

  1. Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
  2. Effects of pomegranate seed oil on lower-extremity ischemia-reperfusion damage: Insights into oxidative stress, inflammation, and cell death.