gut health

Polydextrose Gut Microbiota Randomized Trial Evidence Table

Structured evidence table for Polydextrose Gut Microbiota Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Polydextrose Gut Microbiota Randomized TrialResults Supplementation with RS, but not PD, increased a range of conjugated BAs and deoxycholic acid (FDR Conclusion RS increased plasma BAs, particularly conjugated BAs, whereas PD reduced faecal secondary BA transformation.2Fan J (2026)Distinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
Polydextrose Gut Microbiota Randomized TrialPurpose Dietary fibre may influence bile acid (BA) metabolism via interactions with gut microbiota.2Fan J (2026)Distinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
Polydextrose Gut Microbiota Randomized TrialWe hypothesised that dietary fibres with distinct fermentative properties, resistant starch (RS) and polydextrose (PD), would differentially alter BA profiles in plasma and faeces through gut microbiota-mediated mechanisms.2Fan J (2026)Distinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
Polydextrose Gut Microbiota Randomized TrialAccording to the global disease burden database, the number of patients with IBD increased from 3.32 million in 1990 to 4.9 million in 2019.4Kong Yan (2026)Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
Polydextrose Gut Microbiota Randomized TrialThe area with the highest prevalence rate is high-income North America, where the low-fiber and high-fat diet pattern is an important risk factor for IBD (,).4Kong Yan (2026)Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
Polydextrose Gut Microbiota Randomized TrialAlthough the pathogenesis of IBD is still unclear, it is suggested to be associated with the change of interaction between environment and intestinal microbiota, which leads to the abnormal immune response of genetically susceptible individuals ().4Kong Yan (2026)Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
Polydextrose Gut Microbiota Randomized Trial1 2 3 4 Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease mainly involving the digestive tract.4Kong Yan (2026)Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
topicPolydextrose Gut Microbiota Randomized Trial
claimResults Supplementation with RS, but not PD, increased a range of conjugated BAs and deoxycholic acid (FDR Conclusion RS increased plasma BAs, particularly conjugated BAs, whereas PD reduced faecal secondary BA transformation.
evidence level2
citationFan J (2026)
sourceDistinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
topicPolydextrose Gut Microbiota Randomized Trial
claimPurpose Dietary fibre may influence bile acid (BA) metabolism via interactions with gut microbiota.
evidence level2
citationFan J (2026)
sourceDistinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
topicPolydextrose Gut Microbiota Randomized Trial
claimWe hypothesised that dietary fibres with distinct fermentative properties, resistant starch (RS) and polydextrose (PD), would differentially alter BA profiles in plasma and faeces through gut microbiota-mediated mechanisms.
evidence level2
citationFan J (2026)
sourceDistinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
topicPolydextrose Gut Microbiota Randomized Trial
claimAccording to the global disease burden database, the number of patients with IBD increased from 3.32 million in 1990 to 4.9 million in 2019.
evidence level4
citationKong Yan (2026)
sourcePrebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
topicPolydextrose Gut Microbiota Randomized Trial
claimThe area with the highest prevalence rate is high-income North America, where the low-fiber and high-fat diet pattern is an important risk factor for IBD (,).
evidence level4
citationKong Yan (2026)
sourcePrebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
topicPolydextrose Gut Microbiota Randomized Trial
claimAlthough the pathogenesis of IBD is still unclear, it is suggested to be associated with the change of interaction between environment and intestinal microbiota, which leads to the abnormal immune response of genetically susceptible individuals ().
evidence level4
citationKong Yan (2026)
sourcePrebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota
topicPolydextrose Gut Microbiota Randomized Trial
claim1 2 3 4 Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease mainly involving the digestive tract.
evidence level4
citationKong Yan (2026)
sourcePrebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota

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Source documents

  1. Distinct effects of supplementation with resistant starch and polydextrose on plasma and faecal bile acid profile and associations with gut microbiota: a randomised, controlled intervention in healthy participants.
  2. Prebiotics as adjunctive treatment ameliorates DSS-induced colitis and gut microbiota