topicPistachio Blood Lipids Randomized Trial
claimDiets high in free sugars, particularly from sugar-sweetened beverages (SSBs), are associated with abdominal obesity and increased cardiometabolic risk, prompting global guidelines to limit SSBs as a major public health strategy.
evidence level2
citationErlich MN (2026)
sourceRationale, Design, and Participant Baseline Characteristics of a Parallel Randomized Trial of the Effect of Replacing SSBs with Cow's Milk Versus Soymilk on Intrahepatocellular Lipid and Other Cardiometabolic Risk Factors in Adults with Obesity Who Consume Sugar-Sweetened Beverages: The Soy Treatment Evaluation for Metabolic health (STEM) Trial.
topicPistachio Blood Lipids Randomized Trial
claimFortified soymilk is a plant-based alternative with approved health claims for cholesterol and coronary heart disease risk reduction that offers an equivalent nutritional value to cow's milk.
evidence level2
citationErlich MN (2026)
sourceRationale, Design, and Participant Baseline Characteristics of a Parallel Randomized Trial of the Effect of Replacing SSBs with Cow's Milk Versus Soymilk on Intrahepatocellular Lipid and Other Cardiometabolic Risk Factors in Adults with Obesity Who Consume Sugar-Sweetened Beverages: The Soy Treatment Evaluation for Metabolic health (STEM) Trial.
topicPistachio Blood Lipids Randomized Trial
claimThe Soy Treatment Evaluation for Metabolic (STEM) health trial seeks to evaluate the impact of replacing SSBs with either 2% soymilk or 2% cow's milk on liver fat and other cardiometabolic risk factors in habitual adult consumers of SSBs with obesity.
evidence level2
citationErlich MN (2026)
sourceRationale, Design, and Participant Baseline Characteristics of a Parallel Randomized Trial of the Effect of Replacing SSBs with Cow's Milk Versus Soymilk on Intrahepatocellular Lipid and Other Cardiometabolic Risk Factors in Adults with Obesity Who Consume Sugar-Sweetened Beverages: The Soy Treatment Evaluation for Metabolic health (STEM) Trial.
topicPistachio Blood Lipids Randomized Trial
claimBackground/Objectives : Liver fat represents an early metabolic lesion in the development of diabetes and its cardiometabolic complications.
evidence level2
citationErlich MN (2026)
sourceRationale, Design, and Participant Baseline Characteristics of a Parallel Randomized Trial of the Effect of Replacing SSBs with Cow's Milk Versus Soymilk on Intrahepatocellular Lipid and Other Cardiometabolic Risk Factors in Adults with Obesity Who Consume Sugar-Sweetened Beverages: The Soy Treatment Evaluation for Metabolic health (STEM) Trial.
topicPistachio Blood Lipids Randomized Trial
claimA greater capacity for butyrate production is linked to improved postprandial insulin response [] and reductions in glycated hemoglobin (HbA1c) [], suggesting that pistachios may benefit those with impaired glucose metabolism.
evidence level2
citationRiley Terrence M (2025)
sourceNighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial
topicPistachio Blood Lipids Randomized Trial
claimAlthough pistachios may have glucomodulatory effects among those with prediabetes, type 2 diabetes mellitus (T2DM), and cardiovascular disease risk factors [,], limited work has described the microbial response to pistachio consumption in these populations.
evidence level2
citationRiley Terrence M (2025)
sourceNighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial
topicPistachio Blood Lipids Randomized Trial
claimA study among adults with prediabetes showed that daily pistachio consumption (57 g/d) reduced urine concentrations of hippurate, a microbiota-related metabolite positively associated with insulin resistance and T2DM risk [].
evidence level2
citationRiley Terrence M (2025)
sourceNighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial
topicPistachio Blood Lipids Randomized Trial
claim1 2 3 4 5 6 The human gut microbiota is shaped predominantly by nongenetic factors, of which diet is a key short- and long-term regulator [].
evidence level2
citationRiley Terrence M (2025)
sourceNighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial