heart health

Pine Bark Extract Cardiovascular Meta-Analysis Evidence Table

Structured evidence table for Pine Bark Extract Cardiovascular Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Pine Bark Extract Cardiovascular Meta-AnalysisVisualization of endothelial GCX structures using lectin-based staining with wheat germ agglutinin (WGA) revealed significantly increased WGA intensity (approximately 60%) under dynamic compared to static culture conditions.4Loka Hanna M (2026)Influence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
Pine Bark Extract Cardiovascular Meta-AnalysisWhen cells were dynamically incubated with serum samples obtained from healthy volunteers before and after intake of Pycnogenol®, the WGA signal intensity per cell significantly increased across all conditions.4Loka Hanna M (2026)Influence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
Pine Bark Extract Cardiovascular Meta-AnalysisIn summary, this study demonstrated that dynamic culture conditions promoted the formation of more pronounced glycocalyx-associated surface structures in human endothelial cells compared to static culture.4Loka Hanna M (2026)Influence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
Pine Bark Extract Cardiovascular Meta-AnalysisThe endothelial glycocalyx (GCX) is a major contributor to endothelial cell function and vascular integrity.4Loka Hanna M (2026)Influence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
Pine Bark Extract Cardiovascular Meta-AnalysisPine bark is an extract from the bark of several species of pine trees (Pinus) used in traditional medicine to treat a wide variety of conditions, most frequently to improve cognition, cardiovascular and metabolic health, arthritis and joint pains, and anxiety.4Hoofnagle JH (2025)Pine Bark
Pine Bark Extract Cardiovascular Meta-AnalysisPine bark is generally recognized as safe and has not been linked to serum enzyme elevations during therapy nor to episodes of clinically apparent liver injury.4Hoofnagle JH (2025)Pine Bark
topicPine Bark Extract Cardiovascular Meta-Analysis
claimVisualization of endothelial GCX structures using lectin-based staining with wheat germ agglutinin (WGA) revealed significantly increased WGA intensity (approximately 60%) under dynamic compared to static culture conditions.
evidence level4
citationLoka Hanna M (2026)
sourceInfluence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
topicPine Bark Extract Cardiovascular Meta-Analysis
claimWhen cells were dynamically incubated with serum samples obtained from healthy volunteers before and after intake of Pycnogenol®, the WGA signal intensity per cell significantly increased across all conditions.
evidence level4
citationLoka Hanna M (2026)
sourceInfluence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
topicPine Bark Extract Cardiovascular Meta-Analysis
claimIn summary, this study demonstrated that dynamic culture conditions promoted the formation of more pronounced glycocalyx-associated surface structures in human endothelial cells compared to static culture.
evidence level4
citationLoka Hanna M (2026)
sourceInfluence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
topicPine Bark Extract Cardiovascular Meta-Analysis
claimThe endothelial glycocalyx (GCX) is a major contributor to endothelial cell function and vascular integrity.
evidence level4
citationLoka Hanna M (2026)
sourceInfluence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
topicPine Bark Extract Cardiovascular Meta-Analysis
claimPine bark is an extract from the bark of several species of pine trees (Pinus) used in traditional medicine to treat a wide variety of conditions, most frequently to improve cognition, cardiovascular and metabolic health, arthritis and joint pains, and anxiety.
evidence level4
citationHoofnagle JH (2025)
sourcePine Bark
topicPine Bark Extract Cardiovascular Meta-Analysis
claimPine bark is generally recognized as safe and has not been linked to serum enzyme elevations during therapy nor to episodes of clinically apparent liver injury.
evidence level4
citationHoofnagle JH (2025)
sourcePine Bark

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Source documents

  1. Influence of dietary supplementation with French maritime pine bark extract (Pycnogenol<sup>®</sup>) on endothelial glycocalyx structures in a dynamic cell culture model.
  2. Pine Bark