topicPhytosterols Cholesterol Randomized Trial
claimIntroduction An affordable heart-healthy dietary approach is essential for the management of familial hypercholesterolaemia (FH); however, the optimal dietary pattern and the role of adjunctive nutrient supplementation remain uncertain.
evidence level2
citationde Abreu-Silva EO (2026)
sourceEffect of a culturally adapted heart-healthy diet with phytosterols and/or krill oil on lipid-related outcomes in familial hypercholesterolaemia: protocol for a multicentre randomised controlled trial in Brazil.
topicPhytosterols Cholesterol Randomized Trial
claimThis study aims to evaluate the effects of the Brazilian Cardioprotective Diet (DICA Br), adapted from the Portfolio Diet, with or without phytosterol and/or krill oil supplementation in individuals with probable or definite FH according to the Dutch Lipid Clinic Network (Dutch MEDPED) criteria.
evidence level2
citationde Abreu-Silva EO (2026)
sourceEffect of a culturally adapted heart-healthy diet with phytosterols and/or krill oil on lipid-related outcomes in familial hypercholesterolaemia: protocol for a multicentre randomised controlled trial in Brazil.
topicPhytosterols Cholesterol Randomized Trial
claimMore recently, the focus has shifted to how eating habits can influence and reduce vascular risk.
evidence level4
citationPacinella Gaetano (2026)
sourceThe Mediterranean Diet and Cerebrovascular Risk Factors: A Lifeline for Vascular Health—Narrative Review
topicPhytosterols Cholesterol Randomized Trial
claimThe purpose of this article is to compile and present recent findings on how the MedDiet can lower cerebrovascular risk, while highlighting the pressing need to incorporate nutritional strategies into both medical practice and public health initiatives aimed at preventing vascular diseases.
evidence level4
citationPacinella Gaetano (2026)
sourceThe Mediterranean Diet and Cerebrovascular Risk Factors: A Lifeline for Vascular Health—Narrative Review
topicPhytosterols Cholesterol Randomized Trial
claim7 Most strokes are ischemic and can be traced to changeable lifestyle and metabolic risk factors.
evidence level4
citationPacinella Gaetano (2026)
sourceThe Mediterranean Diet and Cerebrovascular Risk Factors: A Lifeline for Vascular Health—Narrative Review
topicPhytosterols Cholesterol Randomized Trial
claim1 Cerebrovascular disorders, particularly those with ischemic pathogenesis such as ischemic stroke due to vascular occlusion or small vessel disease, continue to be a major contributor to death and lasting disability across the globe, largely fueled by modifiable factors like high blood pressure, dyslipidemia, excess weight, and chronic inflammation.
evidence level4
citationPacinella Gaetano (2026)
sourceThe Mediterranean Diet and Cerebrovascular Risk Factors: A Lifeline for Vascular Health—Narrative Review