Phosphatidylcholine Cognitive Performance Randomized Trial Evidence Table

Structured evidence table for Phosphatidylcholine Cognitive Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Phosphatidylcholine Cognitive Performance Randomized TrialEmerging evidence suggests altered circulating metabolite levels in individuals with Alzheimer's disease (AD) and/or mild cognitive impairment (MCI) compared to healthy controls; how these metabolites alter with early cortical amyloidosis-before symptom onset-remains unclear.4Sharmin T (2026)Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
Phosphatidylcholine Cognitive Performance Randomized TrialAcross the spectrum, lower PC-to-LPC ratios were associated with greater cortical amyloid deposition, poorer cognitive performance and higher plasma P-tau181 levels.4Sharmin T (2026)Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
Phosphatidylcholine Cognitive Performance Randomized TrialElevated Cer(43:1) levels were also associated with higher cortical amyloid deposition.4Sharmin T (2026)Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
Phosphatidylcholine Cognitive Performance Randomized TrialThis cross-sectional study aimed to investigate plasma metabolites obtained through targeted profiling using the Biocrates AbsoluteIDQ® p400 HR kit.4Sharmin T (2026)Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
Phosphatidylcholine Cognitive Performance Randomized TrialBackground The cognitive-enhancing effects of dietary lecithin are gaining increasing attention, but evidence supporting these claims remains limited.4Li X (2026)Association of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
Phosphatidylcholine Cognitive Performance Randomized TrialTargeted lipidomic analysis revealed that the MCI group exhibited a lower total phosphatidylcholine (PC) level, a reduced proportion of PC containing polyunsaturated fatty acid (PUFA), and a higher proportion of PC containing saturated fatty acid (SFA).4Li X (2026)Association of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
Phosphatidylcholine Cognitive Performance Randomized TrialConclusion Higher dietary lecithin intake was associated with better cognitive performance and a lower prevalence of MCI among the elderly population aged 60 and above.4Li X (2026)Association of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
Phosphatidylcholine Cognitive Performance Randomized TrialThis study aims to explore the relationship between dietary lecithin intake and cognitive function, as well as the prevalence of mild cognitive impairment (MCI), in adults aged over 60 years.4Li X (2026)Association of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimEmerging evidence suggests altered circulating metabolite levels in individuals with Alzheimer's disease (AD) and/or mild cognitive impairment (MCI) compared to healthy controls; how these metabolites alter with early cortical amyloidosis-before symptom onset-remains unclear.
evidence level4
citationSharmin T (2026)
sourceCirculating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimAcross the spectrum, lower PC-to-LPC ratios were associated with greater cortical amyloid deposition, poorer cognitive performance and higher plasma P-tau181 levels.
evidence level4
citationSharmin T (2026)
sourceCirculating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimElevated Cer(43:1) levels were also associated with higher cortical amyloid deposition.
evidence level4
citationSharmin T (2026)
sourceCirculating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimThis cross-sectional study aimed to investigate plasma metabolites obtained through targeted profiling using the Biocrates AbsoluteIDQ® p400 HR kit.
evidence level4
citationSharmin T (2026)
sourceCirculating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimBackground The cognitive-enhancing effects of dietary lecithin are gaining increasing attention, but evidence supporting these claims remains limited.
evidence level4
citationLi X (2026)
sourceAssociation of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimTargeted lipidomic analysis revealed that the MCI group exhibited a lower total phosphatidylcholine (PC) level, a reduced proportion of PC containing polyunsaturated fatty acid (PUFA), and a higher proportion of PC containing saturated fatty acid (SFA).
evidence level4
citationLi X (2026)
sourceAssociation of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimConclusion Higher dietary lecithin intake was associated with better cognitive performance and a lower prevalence of MCI among the elderly population aged 60 and above.
evidence level4
citationLi X (2026)
sourceAssociation of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.
topicPhosphatidylcholine Cognitive Performance Randomized Trial
claimThis study aims to explore the relationship between dietary lecithin intake and cognitive function, as well as the prevalence of mild cognitive impairment (MCI), in adults aged over 60 years.
evidence level4
citationLi X (2026)
sourceAssociation of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.

Source documents

  1. Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.
  2. Association of dietary lecithin intake with mild cognitive impairment and cognitive performance in elderly population.