topicParaxanthine Exercise Performance Randomized Trial
claimPerceived exertion was lowest during steady-state exercise in the PRE condition (P Conclusion In summary, ingestion of a pre-exercise supplement containing 200 mg caffeine 35 min before exercise appeared optimal for improved performance in a subsequent fatiguing time trial, possibly by reducing the perception of effort.
evidence level2
citationDavenport AD (2020)
sourceA Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance.
topicParaxanthine Exercise Performance Randomized Trial
claimWhether this was due to increased circulating paraxanthine requires further investigation.
evidence level2
citationDavenport AD (2020)
sourceA Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance.
topicParaxanthine Exercise Performance Randomized Trial
claimBackground Pre-exercise supplements containing low doses of caffeine improve endurance exercise performance, but the most efficacious time for consumption before intense endurance exercise remains unclear, as does the contribution of caffeine metabolism.
evidence level2
citationDavenport AD (2020)
sourceA Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance.
topicParaxanthine Exercise Performance Randomized Trial
claimMethods This study assessed the timing of a commercially available supplement containing 200 mg of caffeine, 1600 mg of β-alanine and 1000 mg of quercetin [Beachbody Performance Energize, Beachbody LLC, USA] on exercise performance, perception of effort and plasma caffeine metabolites.
evidence level2
citationDavenport AD (2020)
sourceA Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance.
topicParaxanthine Exercise Performance Randomized Trial
claimThis study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance.
evidence level4
citationMasters C (2026)
sourceThe Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes.
topicParaxanthine Exercise Performance Randomized Trial
claimThe data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged.
evidence level4
citationMasters C (2026)
sourceThe Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes.