Structured evidence table for Nicotinamide Riboside Muscle Function Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Nicotinamide Riboside Muscle Function Randomized Trial | Aging is accompanied by a decline in physiological function and increased vulnerability to disease, with mitochondrial dysfunction and epigenetic alterations recognized as key hallmarks. | 4 | Heikkinen A (2026) | The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging. |
| Nicotinamide Riboside Muscle Function Randomized Trial | NR supplementation was associated with reduced muscle EAA, particularly when measured with the PCHannum, MEAT, and DunedinPACE clocks, while HIIT produced opposite effects in some clocks, notably increasing pace of aging by DunedinPACE. | 4 | Heikkinen A (2026) | The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging. |
| Nicotinamide Riboside Muscle Function Randomized Trial | Nicotinamide riboside (NR), a vitamin B3 precursor to NAD + , and high-intensity interval training (HIIT) have both been proposed to ameliorate aging-related mitochondrial decline, but their effects on skeletal muscle epigenetic aging are not fully elucidated. | 4 | Heikkinen A (2026) | The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging. |
| Nicotinamide Riboside Muscle Function Randomized Trial | Sarcopenia is an age-related syndrome characterized by progressive loss of skeletal muscle mass and function, which is closely associated with impaired regenerative capacity of muscle satellite cells (MuSCs). | 4 | Li C (2026) | Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism. |
| Nicotinamide Riboside Muscle Function Randomized Trial | We integrate evidence from nearly 60 representative preclinical and clinical studies, clarify the dual-function role of NAD+, and address current inconsistencies in the field. | 4 | Li C (2026) | Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism. |
| Nicotinamide Riboside Muscle Function Randomized Trial | During aging, the MuSC niche undergoes severe deterioration, including mitochondrial dysfunction, chronic inflammation, and neuromuscular junction (NMJ) degeneration, all of which compromise MuSC quiescence, proliferation, and differentiation. | 4 | Li C (2026) | Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism. |
Source documents