topicNiacinamide Skin Hydration Randomized Trial
claimIts pathophysiology involves a deficiency in essential stratum corneum lipids such as ceramides, cholesterol, and free fatty acids, together with reduced levels of natural moisturizing factors (NMFs) and increased TEWL [,].
evidence level2
citationMorgado‐Carrasco Daniel (2026)
sourceEfficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial
topicNiacinamide Skin Hydration Randomized Trial
claimWhile conventional management typically relies on basic emollients and cutaneous hydration [,], there is a growing need for multi‐active formulations that facilitate functional barrier enhancement and address associated symptoms such as pruritus.
evidence level2
citationMorgado‐Carrasco Daniel (2026)
sourceEfficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial
topicNiacinamide Skin Hydration Randomized Trial
claimOn the treated leg, baseline values (33.8 ± 0.8 μS; 95% CI: 32.2–35.4) increased by 16.9% (39.5 ± 0.9 μS; 95% CI: 37.7–41.3) at T7 and 21.6% (41.1 ± 0.8 μS; 95% CI: 39.5–42.7) at T28, both statistically significant in comparison to baseline and to the untreated control ( < 0.05).
evidence level2
citationMorgado‐Carrasco Daniel (2026)
sourceEfficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial
topicNiacinamide Skin Hydration Randomized Trial
claimThe stratum corneum (SC) exhibits a distinctive “bricks and mortar” structure, with protein‐rich corneocytes embedded within a matrix of intercellular lipids [,,].
evidence level2
citationMorgado‐Carrasco Daniel (2026)
sourceEfficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial