Structured evidence table for NAC Oxidative Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| NAC Oxidative Stress Randomized Trial | Preeclampsia with severe features represents an escalation of preeclampsia severity and is associated with a higher risk of adverse maternal and fetal outcomes [,]. | 2 | Okunade Kehinde S. (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol |
| NAC Oxidative Stress Randomized Trial | While certain interventions, such as low-dose aspirin prophylaxis [] in high-risk women, have shown some efficacy in reducing the risk of preeclampsia, there remains a need for additional measures to prevent the development of severe disease in women with early-onset preeclampsia, particularly in resource-constrained settings where the burden of disease is greatest []. | 2 | Okunade Kehinde S. (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol |
| NAC Oxidative Stress Randomized Trial | Currently, the only cure for preeclampsia is delivery of the fetus and placenta [,] however, this is commonly associated with iatrogenic preterm delivery. | 2 | Okunade Kehinde S. (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol |
| NAC Oxidative Stress Randomized Trial | 1 2 3 4 2 5 6 Preeclampsia is a progressive multisystemic complication of pregnancy characterized by hypertension and often proteinuria, typically occurring after 20 weeks of gestation []. | 2 | Okunade Kehinde S. (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol |
| NAC Oxidative Stress Randomized Trial | 1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| NAC Oxidative Stress Randomized Trial | 1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| NAC Oxidative Stress Randomized Trial | Low circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| NAC Oxidative Stress Randomized Trial | In this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials. | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
Source documents