evidence table

N-Acetylcysteine Exercise Recovery Randomized Trial Evidence Table

Structured evidence table for N-Acetylcysteine Exercise Recovery Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
N-Acetylcysteine Exercise Recovery Randomized Trial1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Recovery Randomized Trial1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Recovery Randomized TrialLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Recovery Randomized TrialIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Recovery Randomized Trial—Which populations and contexts (training status, sex and age, dietary pattern and energy availability, heat or hypoxia, and congested competition schedules) shift the balance from benefit to risk?3Mănescu Dan Cristian (2026)Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
N-Acetylcysteine Exercise Recovery Randomized TrialThis review addresses that problem for athletes and practitioners seeking evidence-based guidance.3Mănescu Dan Cristian (2026)Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
N-Acetylcysteine Exercise Recovery Randomized TrialEvidence is organized by outcome domain—training adaptations versus acute performance/recovery—and analyzed through moderators that matter in real programs: class of antioxidant, dose, timing relative to key sessions, training phase, and environmental stress.3Mănescu Dan Cristian (2026)Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
N-Acetylcysteine Exercise Recovery Randomized Trial1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 For decades, exercise-generated reactive oxygen species (ROS) were framed as unavoidable by-products of metabolism whose damage should be “neutralized” [,,,,].3Mănescu Dan Cristian (2026)Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claim1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claim1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claimLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claimIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claim—Which populations and contexts (training status, sex and age, dietary pattern and energy availability, heat or hypoxia, and congested competition schedules) shift the balance from benefit to risk?
evidence level3
citationMănescu Dan Cristian (2026)
sourceAntioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claimThis review addresses that problem for athletes and practitioners seeking evidence-based guidance.
evidence level3
citationMănescu Dan Cristian (2026)
sourceAntioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claimEvidence is organized by outcome domain—training adaptations versus acute performance/recovery—and analyzed through moderators that matter in real programs: class of antioxidant, dose, timing relative to key sessions, training phase, and environmental stress.
evidence level3
citationMănescu Dan Cristian (2026)
sourceAntioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery
topicN-Acetylcysteine Exercise Recovery Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 For decades, exercise-generated reactive oxygen species (ROS) were framed as unavoidable by-products of metabolism whose damage should be “neutralized” [,,,,].
evidence level3
citationMănescu Dan Cristian (2026)
sourceAntioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery

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Source documents

  1. Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
  2. Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery