exercise performance

N-Acetylcysteine Exercise Fatigue Meta-Analysis Evidence Table

Structured evidence table for N-Acetylcysteine Exercise Fatigue Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
N-Acetylcysteine Exercise Fatigue Meta-Analysis1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Fatigue Meta-Analysis1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Fatigue Meta-AnalysisLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Fatigue Meta-AnalysisIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
N-Acetylcysteine Exercise Fatigue Meta-AnalysisFibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic multisystem disorders characterized by persistent fatigue, pain, cognitive dysfunction, sleep disturbances, and reduced quality of life.4Abanades S (2026)Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
N-Acetylcysteine Exercise Fatigue Meta-AnalysisIncreasing evidence implicates mitochondrial dysfunction, oxidative and nitrosative stress, immune dysregulation, and altered redox and nicotinamide adenine dinucleotide (NAD + ) metabolism as interconnected mechanisms contributing to fatigue, although the strength of evidence varies across these pathways.4Abanades S (2026)Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
N-Acetylcysteine Exercise Fatigue Meta-AnalysisThis narrative review critically examines the mechanistic and clinical evidence supporting mitochondrial-oriented micronutritional interventions in fibromyalgia and ME/CFS, including NAD + precursors, B-complex vitamins, magnesium, coenzyme Q10, alpha-lipoic acid, GlyNAC, L-carnitine, pyrroloquinoline quinone, taurine, and creatine.4Abanades S (2026)Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claim1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claim1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claimLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claimIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claimFibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are chronic multisystem disorders characterized by persistent fatigue, pain, cognitive dysfunction, sleep disturbances, and reduced quality of life.
evidence level4
citationAbanades S (2026)
sourceMicronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claimIncreasing evidence implicates mitochondrial dysfunction, oxidative and nitrosative stress, immune dysregulation, and altered redox and nicotinamide adenine dinucleotide (NAD + ) metabolism as interconnected mechanisms contributing to fatigue, although the strength of evidence varies across these pathways.
evidence level4
citationAbanades S (2026)
sourceMicronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.
topicN-Acetylcysteine Exercise Fatigue Meta-Analysis
claimThis narrative review critically examines the mechanistic and clinical evidence supporting mitochondrial-oriented micronutritional interventions in fibromyalgia and ME/CFS, including NAD + precursors, B-complex vitamins, magnesium, coenzyme Q10, alpha-lipoic acid, GlyNAC, L-carnitine, pyrroloquinoline quinone, taurine, and creatine.
evidence level4
citationAbanades S (2026)
sourceMicronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.

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Source documents

  1. Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
  2. Micronutrition as a Therapeutic Strategy for Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Narrative Review.