topicMyo-Inositol Metabolic Health Randomized Trial
claimConclusion MI-based therapy, particularly early initiation and strategic combinations, should be integrated into multimodal management of PCOS-related cutaneous manifestations.
evidence level2
citationGanjoo A (2026)
sourceMyo-Inositol for Cutaneous Manifestations of Polycystic Ovary Syndrome: An International Delphi Consensus Recommendation for Dermatology Practice.
topicMyo-Inositol Metabolic Health Randomized Trial
claimPurpose Acne and hirsutism are among the most distressing features of polycystic ovary syndrome (PCOS), yet current guidelines largely emphasize metabolic and reproductive aspects, offering limited guidance for dermatologic management.
evidence level2
citationGanjoo A (2026)
sourceMyo-Inositol for Cutaneous Manifestations of Polycystic Ovary Syndrome: An International Delphi Consensus Recommendation for Dermatology Practice.
topicMyo-Inositol Metabolic Health Randomized Trial
claimMyo-inositol (MI), an insulin-sensitizing agent with endocrine benefits, has emerged as a promising nonhormonal option; however, its role in managing cutaneous symptoms remains unclear.
evidence level2
citationGanjoo A (2026)
sourceMyo-Inositol for Cutaneous Manifestations of Polycystic Ovary Syndrome: An International Delphi Consensus Recommendation for Dermatology Practice.
topicMyo-Inositol Metabolic Health Randomized Trial
claimAnxiety and depressive disorders frequently co-occur, and converging evidence from symptom profiles, longitudinal course, shared neurobiological markers, familial aggregation, and treatment response supports a substantial overlap between these conditions [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Metabolic Health Randomized Trial
claimImportantly, even agents considered comparatively “benign”, such as non-benzodiazepine anxiolytics, may rarely cause significant neurological adverse effects in vulnerable individuals, as illustrated by reports of buspirone-associated dyskinesia or dystonia, plausibly related to its interactions with dopaminergic signaling [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Metabolic Health Randomized Trial
claimRecent reports have also raised the possibility that selected cyclitols may exert anxiolytic activity; however, robust clinical evidence remains scarce, and the available data are largely preliminary, often derived from indirect observations or preclinical research [].
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review
topicMyo-Inositol Metabolic Health Randomized Trial
claim1 2 3 4 1 Anxiety plays a dual role, encompassing both adaptive and maladaptive dimensions.
evidence level4
citationDerkaczew Maria (2026)
sourcePotential Anxiolytic Effects of Selected Inositol Stereoisomers—A Narrative Review