Structured evidence table for Myo-Inositol Insulin Sensitivity Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Myo-Inositol Insulin Sensitivity Randomized Trial | The global prevalence of PCOS increased from 36.7 to 69.5 million between 1990 and 2021. | 3 | Subakathulla Sumayyah (2026) | Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails? |
| Myo-Inositol Insulin Sensitivity Randomized Trial | Emerging evidence underscores that OS is not a mere byproduct of metabolic imbalance but a central driver that disrupts insulin signaling, amplifies androgen biosynthesis, and impairs folliculogenesis (,). | 3 | Subakathulla Sumayyah (2026) | Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails? |
| Myo-Inositol Insulin Sensitivity Randomized Trial | Low-dose variants of OCPs have been observed with an increased risk of myocardial infarction and cardiovascular arterial disease (). | 3 | Subakathulla Sumayyah (2026) | Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails? |
| Myo-Inositol Insulin Sensitivity Randomized Trial | 1 2 3 4 5 Polycystic ovary syndrome (PCOS) represents one of the most complex endocrine-metabolic disorders affecting women of reproductive age, characterized by a collection of reproductive, metabolic, and psychological manifestations (,). | 3 | Subakathulla Sumayyah (2026) | Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails? |
| Myo-Inositol Insulin Sensitivity Randomized Trial | This narrative review critically evaluates current evidence on the role of D-pinitol in glucose homeostasis and energy balance, integrating data from chemical characterization studies, mechanistic research, preclinical models, and human clinical trials assessing purified D-pinitol and D-pinitol-rich preparations, particularly from carob-derived sources. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Myo-Inositol Insulin Sensitivity Randomized Trial | Available evidence suggests that D-pinitol may enhance insulin signaling efficiency, primarily through PI3K/Akt-dependent pathways, modulate hepatic metabolic flexibility, and influence endocrine balance without acting as a classical hypoglycemic agent. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Myo-Inositol Insulin Sensitivity Randomized Trial | The global rise in obesity and metabolic disorders has intensified interest in dietary bioactives capable of improving glycemic control and metabolic health. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
| Myo-Inositol Insulin Sensitivity Randomized Trial | Inositols, particularly D-pinitol, have emerged as insulin-sensitizing cyclitols with potential metabolic relevance. | 4 | Torres-Oteros D (2026) | Carob (<i>Ceratonia siliqua</i> L.) in Glucose Homeostasis and Energy Balance: The Role of D-Pinitol. |
Source documents