Structured evidence table for Myo-Inositol Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Myo-Inositol Cognition Randomized Trial | Introduction Observational studies link the MIND diet to reduced risk of Alzheimer's disease (AD) and slower cognitive decline. | 2 | Voigt RM (2026) | Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial. |
| Myo-Inositol Cognition Randomized Trial | However, a recent randomized controlled trial found no differential cognitive benefit of the MIND diet over a control diet in the context of shared caloric restriction. | 2 | Voigt RM (2026) | Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial. |
| Myo-Inositol Cognition Randomized Trial | Prospective modeling independent of diet group revealed that a poorer cognitive trajectory was significantly associated with increased inositol degradation (PWY-7237) and purine nucleotide salvage (PWY66-409); conversely, a better cognitive trajectory was associated with increased degradation of deoxy sugars (FUC-RHAMCAT-PWY). | 2 | Voigt RM (2026) | Weight loss and metabolic improvements dominate the microbiome response in the MIND diet intervention: a randomized controlled trial. |
| Myo-Inositol Cognition Randomized Trial | BACKGROUND: Observational studies have linked high adherence to the “Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay” (MIND) diet to improved cognitive functions in older adults. | 3 | Remie LB (2026) | MIND-NL diet adherence moderates the relation of low-grade systemic inflammation with neuroinflammatory metabolites and cognitive functioning: an exploratory cross-sectional study in older adults. |
| Myo-Inositol Cognition Randomized Trial | Neuroinflammation-associated metabolites (myo-inositol, choline and creatine) were measured in the dorsolateral prefrontal cortex with proton magnetic resonance spectroscopy (1H-MRS). | 3 | Remie LB (2026) | MIND-NL diet adherence moderates the relation of low-grade systemic inflammation with neuroinflammatory metabolites and cognitive functioning: an exploratory cross-sectional study in older adults. |
| Myo-Inositol Cognition Randomized Trial | CONCLUSION: Our findings show that MIND diet adherence modulates inflammation-brain relationships in aging, with detrimental associations between systemic inflammation and both neuroinflammation and cognitive functioning observed only in individuals with lower adherence. | 3 | Remie LB (2026) | MIND-NL diet adherence moderates the relation of low-grade systemic inflammation with neuroinflammatory metabolites and cognitive functioning: an exploratory cross-sectional study in older adults. |
| Myo-Inositol Cognition Randomized Trial | The underlying peripheral and central mechanisms of this association remain poorly understood, although multiple nutrients in the MIND diet are known for their anti-inflammatory effects. | 3 | Remie LB (2026) | MIND-NL diet adherence moderates the relation of low-grade systemic inflammation with neuroinflammatory metabolites and cognitive functioning: an exploratory cross-sectional study in older adults. |
Source documents