evidence table

Milk Thistle Fatigue Randomized Trial Evidence Table

Structured evidence table for Milk Thistle Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Milk Thistle Fatigue Randomized Trial1 2 1 3 4 5 6 Metabolic dysfunction-associated steatotic liver disease [MASLD; formerly known as non-alcoholic fatty liver disease (NAFLD)] is caused by chronic fat deposition in the liver and is the result of complex interactions involving metabolic dysregulation and insulin resistance ().2Messier Helen (2026)Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
Milk Thistle Fatigue Randomized TrialSome patients with MASLD will have metabolic dysfunction-associated steatohepatitis (MASH) which is characterized by hepatocellular ballooning and lobular inflammation ().2Messier Helen (2026)Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
Milk Thistle Fatigue Randomized TrialMASLD is associated with the development of cirrhosis, liver failure, liver cancer, and type 2 diabetes ().2Messier Helen (2026)Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
Milk Thistle Fatigue Randomized TrialImaging tests, including FibroScan, which estimates the amount of fat and fibrosis present in the liver, are used to look for signs of MASLD ().2Messier Helen (2026)Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
Milk Thistle Fatigue Randomized TrialDiscussion Supplementation with this liquid nutraceutical formula improved the liver enzyme profile of healthy individuals, suggesting that it may mitigate a trend toward higher liver enzyme levels over time in a convenient manner that fosters compliance.2Patel G (2026)Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
Milk Thistle Fatigue Randomized TrialWhile numerous herbal extracts have individually been shown to improve liver function, there are relatively few studies on combinations of herbal ingredients that may have synergistic effects.2Patel G (2026)Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
Milk Thistle Fatigue Randomized TrialIn addition, capsule fatigue is a common problem when aiming to incorporate multiple ingredients to support liver health.2Patel G (2026)Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
topicMilk Thistle Fatigue Randomized Trial
claim1 2 1 3 4 5 6 Metabolic dysfunction-associated steatotic liver disease [MASLD; formerly known as non-alcoholic fatty liver disease (NAFLD)] is caused by chronic fat deposition in the liver and is the result of complex interactions involving metabolic dysregulation and insulin resistance ().
evidence level2
citationMessier Helen (2026)
sourceEffectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
topicMilk Thistle Fatigue Randomized Trial
claimSome patients with MASLD will have metabolic dysfunction-associated steatohepatitis (MASH) which is characterized by hepatocellular ballooning and lobular inflammation ().
evidence level2
citationMessier Helen (2026)
sourceEffectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
topicMilk Thistle Fatigue Randomized Trial
claimMASLD is associated with the development of cirrhosis, liver failure, liver cancer, and type 2 diabetes ().
evidence level2
citationMessier Helen (2026)
sourceEffectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
topicMilk Thistle Fatigue Randomized Trial
claimImaging tests, including FibroScan, which estimates the amount of fat and fibrosis present in the liver, are used to look for signs of MASLD ().
evidence level2
citationMessier Helen (2026)
sourceEffectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
topicMilk Thistle Fatigue Randomized Trial
claimDiscussion Supplementation with this liquid nutraceutical formula improved the liver enzyme profile of healthy individuals, suggesting that it may mitigate a trend toward higher liver enzyme levels over time in a convenient manner that fosters compliance.
evidence level2
citationPatel G (2026)
sourceLong-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
topicMilk Thistle Fatigue Randomized Trial
claimWhile numerous herbal extracts have individually been shown to improve liver function, there are relatively few studies on combinations of herbal ingredients that may have synergistic effects.
evidence level2
citationPatel G (2026)
sourceLong-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
topicMilk Thistle Fatigue Randomized Trial
claimIn addition, capsule fatigue is a common problem when aiming to incorporate multiple ingredients to support liver health.
evidence level2
citationPatel G (2026)
sourceLong-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.

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Source documents

  1. Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial
  2. Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.