topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimResults ASM increased significantly in the TLN-01 group (+0.42 kg, +3.2%; p p = 0.785), with a significant between-group difference (ANCOVA p p = 0.32); within-group analysis showed a significant decline in the placebo group (-7.0%; p p = 0.537).
evidence level2
citationChan DC (2026)
sourceEffects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial.
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimMetabolomic analysis revealed reductions in plasma taurine and 1-methylhistidine and an increase in kynurenine; given the absence of clear separation on PCA/PLS-DA, these findings are considered exploratory and hypothesis-generating rather than confirmatory evidence of altered amino acid utilization or proteolysis.
evidence level2
citationChan DC (2026)
sourceEffects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial.
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimBackground Sarcopenia, the age-related loss of muscle mass and strength, affects over 20% of older adults in Taiwan and contributes to frailty and functional decline.
evidence level2
citationChan DC (2026)
sourceEffects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial.
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimNutritional supplementation offers a promising strategy for those unable to engage in structured exercise, yet multi-ingredient MCT-leucine-creatine-based interventions remain understudied in clinically defined sarcopenic populations.
evidence level2
citationChan DC (2026)
sourceEffects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial.
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimThe medical and clinical applications of MCTs are diverse and include, among other things, the management of gastrointestinal disorders associated with fat malabsorption (), their use in weight management strategies (), and therapeutic approaches for neurological conditions such as epilepsy and Alzheimer's disease ().
evidence level3
citationScheller Marc (2026)
sourceGastrointestinal issues predominate among side effects of medium-chain triglyceride consumption in humans
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimDespite the broad range of potential applications and increasing public interest, the current body of evidence on MCT efficacy, safety, and tolerability of MCTs is limited and partly conflicting, warranting further systematic research (–).
evidence level3
citationScheller Marc (2026)
sourceGastrointestinal issues predominate among side effects of medium-chain triglyceride consumption in humans
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claimMany commercial claims seem to exceed the strength of the current scientific evidence, highlighting the need for cautious interpretation.
evidence level3
citationScheller Marc (2026)
sourceGastrointestinal issues predominate among side effects of medium-chain triglyceride consumption in humans
topicMedium Chain Triglycerides Exercise Performance Randomized Trial
claim1 2 3 2 4 6 7 8 9 10 11 12 13 14 15 16 17 20 12 21 23 24 27 28 30 19 16 31 Medium-chain triglycerides (MCTs) are receiving increasing attention in various fields of medical and dietetic research, including the treatment and prevention of dietary conditions ().
evidence level3
citationScheller Marc (2026)
sourceGastrointestinal issues predominate among side effects of medium-chain triglyceride consumption in humans