topicMct Oil Cognitive Performance Randomized Trial
claimEK supplementation was associated with a statistically significant improvement in cognitive performance compared with placebo (SMD = 0.29, 95% CI 0.16-0.41; p p = 0.083), study duration (acute vs.
evidence level1
citationBonnechère B (2026)
sourceThe effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis.
topicMct Oil Cognitive Performance Randomized Trial
claimDiscussion EK supplementation is associated with modest improvements in cognitive performance across diverse populations and study designs.
evidence level1
citationBonnechère B (2026)
sourceThe effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis.
topicMct Oil Cognitive Performance Randomized Trial
claimIntroduction Cognitive function is closely linked to brain energy metabolism and may be compromised by aging, metabolic stress, and neuropsychiatric disease.
evidence level1
citationBonnechère B (2026)
sourceThe effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis.
topicMct Oil Cognitive Performance Randomized Trial
claimKetone bodies can serve as an alternative cerebral fuel and may also exert signaling effects relevant to cognition.
evidence level1
citationBonnechère B (2026)
sourceThe effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis.
topicMct Oil Cognitive Performance Randomized Trial
claimThe potential benefits of KD are explored across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, based on both preclinical and clinical evidence that supports its feasibility.
evidence level4
citationSalgueiro AM (2026)
sourceKetogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.
topicMct Oil Cognitive Performance Randomized Trial
claimThis review underscores the potential of KD for treating neurodegeneration on the basis of current scientific evidence while highlighting the need for further research to optimize its application and address existing gaps.
evidence level4
citationSalgueiro AM (2026)
sourceKetogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.
topicMct Oil Cognitive Performance Randomized Trial
claimThe ketogenic diet (KD) is increasingly recognized as a promising therapeutic strategy for neurodegenerative disorders because of its multifaceted impacts on key pathophysiological mechanisms.
evidence level4
citationSalgueiro AM (2026)
sourceKetogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.
topicMct Oil Cognitive Performance Randomized Trial
claimThis review explores the molecular pathways through which KD may protect against neurodegeneration, including the use of ketone bodies as alternative energy substrates, reduction of oxidative stress and inflammation, modulation of autophagy and protein aggregation, and impact on the gut microbiome.
evidence level4
citationSalgueiro AM (2026)
sourceKetogenic diet as a therapeutic strategy for neurodegenerative diseases: from mechanisms to translational challenges.