topicManganese Oxidative Stress Randomized Trial
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicManganese Oxidative Stress Randomized Trial
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicManganese Oxidative Stress Randomized Trial
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicManganese Oxidative Stress Randomized Trial
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicManganese Oxidative Stress Randomized Trial
claim1 2 3 4 Diabetic retinal disease (DRD) is classically understood as a disease of the retinal microvasculature due to the characteristic microvascular changes—including microaneurysm formation, selective pericyte loss, and capillary dropout—associated with the condition [,].
evidence level3
citationCarter William C. (2026)
sourceExplaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology
topicManganese Oxidative Stress Randomized Trial
claimBecause photoreceptor glucose uptake relies on insulin-independent GLUT1 and GLUT3 channels, hyperglycemic conditions result in an unchecked accumulation of cytosolic glucose [,].
evidence level3
citationCarter William C. (2026)
sourceExplaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology
topicManganese Oxidative Stress Randomized Trial
claimFigure 1 This review evaluates the evidence supporting both distinct mechanisms of diabetic retinal injury, which are summarized in.
evidence level3
citationCarter William C. (2026)
sourceExplaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology
topicManganese Oxidative Stress Randomized Trial
claimThis unites DRD with other end-organ manifestations of diabetes in which microvascular damage is known to play a central role, such as diabetic nephropathy and neuropathy.
evidence level3
citationCarter William C. (2026)
sourceExplaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology