topicManganese Bone Density Randomized Trial
claimDysregulation manifests as lipid abnormalities in obesity, insulin resistance associated with type 2 diabetes mellitus (T2DM), hepatic steatosis, and chronic low-grade inflammation, all of which have a multifaceted impact on bone homeostasis.
evidence level3
citationBasak Sanjay (2026)
sourceRoles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis
topicManganese Bone Density Randomized Trial
claimRecent evidence has highlighted the coexistence of obesity or T2DM with various bone disorders (,).
evidence level3
citationBasak Sanjay (2026)
sourceRoles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis
topicManganese Bone Density Randomized Trial
claimHigh-resolution metabolomics has identified that spinal bone mineral density is associated with several metabolic pathways, including fatty acid activation and biosynthesis, glycerophospholipid metabolism, and linoleic acid metabolism ().
evidence level3
citationBasak Sanjay (2026)
sourceRoles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis
topicManganese Bone Density Randomized Trial
claim1 2 3 4 5 6 7 7 Metabolic dysregulation involves significant alterations in normal metabolic processes and is a key factor in the development of pathological changes.
evidence level3
citationBasak Sanjay (2026)
sourceRoles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis
topicManganese Bone Density Randomized Trial
claimPurpose This review aimed to evaluate the existing evidence on the effects of dietary factors and nutrients on dental implant osseointegration.
evidence level4
citationSodnom-Ish B (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.
topicManganese Bone Density Randomized Trial
claimMost studies focused on vitamin D, whereas evidence for other micronutrients was limited.
evidence level4
citationSodnom-Ish B (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.
topicManganese Bone Density Randomized Trial
claimFive studies reported no significant association, while two studies investigating vitamin B and vitamin C showed that vitamin B did not influence postoperative pain or paresthesia and vitamin C improved soft tissue healing.
evidence level4
citationSodnom-Ish B (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.
topicManganese Bone Density Randomized Trial
claimMethods This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines.
evidence level4
citationSodnom-Ish B (2026)
sourceThe effect of dietary factors and nutrients on osseointegration, dental implant success and survival: a scoping review.