topicMaca Wellbeing Randomized Trial
claimConclusion Compared to standard multimodal analgesia, low-dose ITM significantly reduced postoperative pain and analgesic consumption, and prolonged the time to first analgesic administration, without an increased incidence or severity of adverse effects in elderly patients with HF.
evidence level2
citationBuršík D (2026)
sourceLow-Dose Morphine Intrathecal Analgesia in Elderly Patients with Hip Fracture Undergoing Single Spinal Anesthesia: A Randomized Controlled Trial.
topicMaca Wellbeing Randomized Trial
claimBackground Hip fractures (HF) are a serious and increasingly common condition in the geriatric population.
evidence level2
citationBuršík D (2026)
sourceLow-Dose Morphine Intrathecal Analgesia in Elderly Patients with Hip Fracture Undergoing Single Spinal Anesthesia: A Randomized Controlled Trial.
topicMaca Wellbeing Randomized Trial
claimFavorable clinical outcomes require early postoperative rehabilitation, which relies on effective pain management.
evidence level2
citationBuršík D (2026)
sourceLow-Dose Morphine Intrathecal Analgesia in Elderly Patients with Hip Fracture Undergoing Single Spinal Anesthesia: A Randomized Controlled Trial.
topicMaca Wellbeing Randomized Trial
claimThis is largely caused by the challenges associated with implementing the ECPR program in larger regions due to the technological demands, need for highly experienced personnel, substantial costs, and, last but not least, because current evidence from randomized controlled trials (ARREST trial, Prague OHCA and Inception trial) shows slightly conflicting results [–].
evidence level4
citationBurša Filip (2026)
sourceExtracorporeal cardiopulmonary resuscitation in a large tertiary center in the Czech Republic: three years’ experience and future directions
topicMaca Wellbeing Randomized Trial
claimSF36 is a standardized questionnaire measuring the quality of life in 8 domains, each rated 0 (worst) to 100 (best), with scores < 40 indicating reduced quality of life compared to the general population.
evidence level4
citationBurša Filip (2026)
sourceExtracorporeal cardiopulmonary resuscitation in a large tertiary center in the Czech Republic: three years’ experience and future directions
topicMaca Wellbeing Randomized Trial
claimSecondary analyses of the above-mentioned RCTs showed association of ECPR with improved neurologic outcomes [,] and pooled data from ARREST and Prague OHCA studies showed better survival with favorable neurologic outcomes at 180 days in the ECPR vs control group (32.4% vs 19.7%; p = 0.015; 47.1% vs 28.3% in the shockable rhythm-only analysis; p = 0.01) [].
evidence level4
citationBurša Filip (2026)
sourceExtracorporeal cardiopulmonary resuscitation in a large tertiary center in the Czech Republic: three years’ experience and future directions
topicMaca Wellbeing Randomized Trial
claim1 3 4 5 6 7 8 10 Patients undergoing conventional cardiopulmonary resuscitation (CCPR) due to out-of-hospital cardiac arrest (OHCA) have a poor prognosis, with favorable long-term neurologic outcome achieved in only approximately 10% of cases [–].
evidence level4
citationBurša Filip (2026)
sourceExtracorporeal cardiopulmonary resuscitation in a large tertiary center in the Czech Republic: three years’ experience and future directions