topicMaca Sexual Function Randomized Trial
claimIt drives many physiological, emotional, and mental shifts that occur during this transition, including vasomotor symptoms, bone loss, alterations in body composition, changes in mood and cognition, and increased cardiometabolic risk [].
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Sexual Function Randomized Trial
claim29 30 31 32 33 Historically, this rise with the transition from the reproductive to menopausal stage of life has been interpreted primarily as a compensatory response to declining ovarian function and reduced negative feedback from the ovaries [].
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Sexual Function Randomized Trial
claim34 35 36 37 34 38 39 40 Another point of consideration is the evidence accumulating for FSH’s actions beyond the ovary.
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Sexual Function Randomized Trial
claim1 2 3 4 Over the past two decades, perimenopause and menopause have emerged as prominent topics in medical and public discourse.
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging