topicMaca Menopause Randomized Trial
claimThis study aims to use a network meta-analysis (NMA) to compare the effectiveness and safety of various dietary supplements based on outcomes such as hair density and terminal hair density, providing evidence-based support for clinical decision-making.
evidence level1
citationZhou L (2026)
sourceEffects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
topicMaca Menopause Randomized Trial
claimStata 16.0 software was used for network meta-analysis, and Revman 5.4 software was utilized for evaluating study quality and bias risk; additionally, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was applied to rate the certainty (quality) of evidence for the included studies.
evidence level1
citationZhou L (2026)
sourceEffects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
topicMaca Menopause Randomized Trial
claimResults showed that compared with placebo, standardized plant extracts (Nutrafol), apple extract (AMSbzs, AMS), tocotrienols, pumpkin seed oil (PSO), and a compound extract of Cistanche and Laminaria (MK-R7) significantly improved hair density.
evidence level1
citationZhou L (2026)
sourceEffects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
topicMaca Menopause Randomized Trial
claimBackground In recent years, androgenetic alopecia (AGA) has emerged as a significant public health concern due to its high prevalence and progressive nature.
evidence level1
citationZhou L (2026)
sourceEffects of dietary supplements on androgenetic alopecia: a systematic review and network meta-analysis.
topicMaca Menopause Randomized Trial
claimBackground: Middle-aged women frequently experience diverse physical and psychological symptoms, including depression, anxiety, sleep disturbances, vasomotor symptoms, and reduced quality of life, during menopause.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimRisk of bias was assessed using the Cochrane risk of bias tool, and meta-analyses were performed using a random effects model.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimResults: Nonpharmacological interventions significantly reduced symptoms of depression (standardized mean difference (SMD) = -1.10), anxiety (-0.82), sleep disturbances (-0.90), menopausal symptoms (-1.18), and hot flashes (-0.34).
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimWith increasing concerns regarding the side effects of hormone therapy, nonpharmacological interventions have emerged as safer alternatives for symptom management.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.