topicMaca Menopause Randomized Trial
claimBackground: Middle-aged women frequently experience diverse physical and psychological symptoms, including depression, anxiety, sleep disturbances, vasomotor symptoms, and reduced quality of life, during menopause.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimRisk of bias was assessed using the Cochrane risk of bias tool, and meta-analyses were performed using a random effects model.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimResults: Nonpharmacological interventions significantly reduced symptoms of depression (standardized mean difference (SMD) = -1.10), anxiety (-0.82), sleep disturbances (-0.90), menopausal symptoms (-1.18), and hot flashes (-0.34).
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimWith increasing concerns regarding the side effects of hormone therapy, nonpharmacological interventions have emerged as safer alternatives for symptom management.
evidence level1
citationKim JH (2025)
sourceNonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis.
topicMaca Menopause Randomized Trial
claimData synthesis was performed with RevMan 5.4, and the certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
evidence level1
citationde Aquino ACQ (2025)
sourcePharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials.
topicMaca Menopause Randomized Trial
claimis the most effective pharmacological treatment for AISD in women, though the evidence quality is low.
evidence level1
citationde Aquino ACQ (2025)
sourcePharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials.
topicMaca Menopause Randomized Trial
claimBackground Antidepressant-Induced Sexual Dysfunction (AISD) is a significant public health concern, and pharmacological treatments may offer potential solutions for managing this side effect.
evidence level1
citationde Aquino ACQ (2025)
sourcePharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials.
topicMaca Menopause Randomized Trial
claimThis study aims to assess the efficacy of these therapies in treating AISD in women, as well as their impact on improving depressive symptoms.
evidence level1
citationde Aquino ACQ (2025)
sourcePharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials.