topicMaca Menopausal Symptoms Randomized Trial
claimIt drives many physiological, emotional, and mental shifts that occur during this transition, including vasomotor symptoms, bone loss, alterations in body composition, changes in mood and cognition, and increased cardiometabolic risk [].
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Menopausal Symptoms Randomized Trial
claim29 30 31 32 33 Historically, this rise with the transition from the reproductive to menopausal stage of life has been interpreted primarily as a compensatory response to declining ovarian function and reduced negative feedback from the ovaries [].
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Menopausal Symptoms Randomized Trial
claim34 35 36 37 34 38 39 40 Another point of consideration is the evidence accumulating for FSH’s actions beyond the ovary.
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Menopausal Symptoms Randomized Trial
claim1 2 3 4 Over the past two decades, perimenopause and menopause have emerged as prominent topics in medical and public discourse.
evidence level3
citationMinich Deanna (2026)
sourceIs Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging
topicMaca Menopausal Symptoms Randomized Trial
claimDepression can impair desire, arousal, orgasm and satisfaction before pharmacotherapy, while serotonergic antidepressants may further disturb these domains during treatment, complicating causal attribution and underscoring the need to distinguish depression-related sexual dysfunction from antidepressant-associated sexual dysfunction (AISD).
evidence level4
citationLiu X (2026)
sourcePlant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.
topicMaca Menopausal Symptoms Randomized Trial
claimWe conducted a narrative review based on targeted searches of PubMed/MEDLINE, Web of Science and Scopus through June 2026, synthesizing mechanistic and clinical evidence for selected candidates by phenotype specificity to separate direct AISD studies from adjacent clinical or preclinical evidence and mechanistic plausibility.
evidence level4
citationLiu X (2026)
sourcePlant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.
topicMaca Menopausal Symptoms Randomized Trial
claimSaffron provides the most coherent AISD-specific signal, supported by small randomized trials in women and men with fluoxetine-associated sexual dysfunction.
evidence level4
citationLiu X (2026)
sourcePlant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.
topicMaca Menopausal Symptoms Randomized Trial
claimSexual dysfunction related to depression and antidepressant treatment is clinically important yet underrecognized, affecting adherence, intimate functioning and quality of life.
evidence level4
citationLiu X (2026)
sourcePlant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.