topicMaca Fatigue Randomized Trial
claimIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Randomized Trial
claimThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Randomized Trial
claimSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Randomized Trial
claimIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicMaca Fatigue Randomized Trial
claimEvidence for switching to vilazodone to treat AISD is conflicting, as is data surrounding the effect of Ginkgo biloba on AISD.
evidence level4
citationTran FD (2025)
sourceManagement of Antidepressant-Induced Sexual Dysfunction: A Literature Review.
topicMaca Fatigue Randomized Trial
claimAlthough selective serotonin reuptake inhibitors (SSRIs) are the mainstay of treatment for various psychiatric conditions, including but not limited to major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, and bulimia nervosa, sexual side effects from these medications are common.
evidence level4
citationTran FD (2025)
sourceManagement of Antidepressant-Induced Sexual Dysfunction: A Literature Review.
topicMaca Fatigue Randomized Trial
claimThese side effects include decreased libido, difficulty with arousal and erection, and delayed or absent orgasm, which can be troubling for many patients and impact adherence to treatment and quality of life.
evidence level4
citationTran FD (2025)
sourceManagement of Antidepressant-Induced Sexual Dysfunction: A Literature Review.