topicMaca Cognition Randomized Trial
claimBackground : Atrial fibrillation (AF) significantly impacts the clinical and financial burden of healthcare systems worldwide.
evidence level4
citationSokolova E (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model.
topicMaca Cognition Randomized Trial
claimPatient-reported outcomes (PROMs) are considered a core element of patient-centered care.
evidence level4
citationSokolova E (2026)
sourceIntegrating Patient-Reported Outcomes into Clinical Pathways in Atrial Fibrillation: A Framework Aligned with the AF-CARE Model.
topicMaca Cognition Randomized Trial
claimBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Cognition Randomized Trial
claimThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicMaca Cognition Randomized Trial
claimWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.