topicLutein Visual Performance Randomized Trial
claimHowever, these approaches require repeated invasive injections and are associated with considerable economic burden and procedural risks [,].
evidence level1
citationWang Wei-Xiang (2026)
sourceFrom Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
topicLutein Visual Performance Randomized Trial
claimExperimental and clinical studies have suggested that increased macular pigment levels may support visual performance and potentially attenuate AMD progression [–].
evidence level1
citationWang Wei-Xiang (2026)
sourceFrom Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
topicLutein Visual Performance Randomized Trial
claimSome findings from the Age‐Related Eye Disease Study 2 (AREDS2) indicated that lutein and zeaxanthin supplementation significantly reduced the risk of progression to late‐stage AMD [].
evidence level1
citationWang Wei-Xiang (2026)
sourceFrom Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
topicLutein Visual Performance Randomized Trial
claim1 2 3 4 5 6 7 Age‐related macular degeneration (AMD) remains one of the leading causes of irreversible central vision loss among individuals over 65 years of age worldwide.
evidence level1
citationWang Wei-Xiang (2026)
sourceFrom Supplements to Sight: Quantifying the Impact of Lutein and Carotenoid on Age‐Related Macular Degeneration—A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
topicLutein Visual Performance Randomized Trial
claimThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Performance Randomized Trial
claimEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Performance Randomized Trial
claimTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Performance Randomized Trial
claimBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.