evidence table

Lutein Visual Fatigue Randomized Trial Evidence Table

Structured evidence table for Lutein Visual Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Lutein Visual Fatigue Randomized TrialThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Visual Fatigue Randomized TrialEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Visual Fatigue Randomized TrialTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Visual Fatigue Randomized TrialBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Visual Fatigue Randomized Trial7 9 The standard of care for many IRDs has largely focused on managing associated complications and the use of optical aids to improve quality of life.4Barthelemy Normila (2026)Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
Lutein Visual Fatigue Randomized TrialThis review synthesizes both historical and contemporary evidence regarding dietary and nutritional interventions for IRDs.  14 Retinitis pigmentosa is one of the most common IRDs and is characterized by progressive photoreceptor cell death.4Barthelemy Normila (2026)Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
Lutein Visual Fatigue Randomized TrialBy applying next-generation sequencing (NGS) technology to DNA samples stored from patients of the previous vitamin A trials, they were able to identify the specific RP gene variants for most participants and the lack of protective effect across genetic subtypes such as,and-associated retinitis pigmentosa [].4Barthelemy Normila (2026)Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
Lutein Visual Fatigue Randomized Trial1 4 5 6 Inherited retinal diseases (IRDs) comprise a complex group of heterogenous disorders that lead to progressive retinal cell death and functional vision loss.4Barthelemy Normila (2026)Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Visual Fatigue Randomized Trial
claimThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Fatigue Randomized Trial
claimEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Fatigue Randomized Trial
claimTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Fatigue Randomized Trial
claimBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Visual Fatigue Randomized Trial
claim7 9 The standard of care for many IRDs has largely focused on managing associated complications and the use of optical aids to improve quality of life.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Visual Fatigue Randomized Trial
claimThis review synthesizes both historical and contemporary evidence regarding dietary and nutritional interventions for IRDs.  14 Retinitis pigmentosa is one of the most common IRDs and is characterized by progressive photoreceptor cell death.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Visual Fatigue Randomized Trial
claimBy applying next-generation sequencing (NGS) technology to DNA samples stored from patients of the previous vitamin A trials, they were able to identify the specific RP gene variants for most participants and the lack of protective effect across genetic subtypes such as,and-associated retinitis pigmentosa [].
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Visual Fatigue Randomized Trial
claim1 4 5 6 Inherited retinal diseases (IRDs) comprise a complex group of heterogenous disorders that lead to progressive retinal cell death and functional vision loss.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease

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Source documents

  1. Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
  2. Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease