evidence table

Lutein Supplementation Eye Strain Randomized Trial Evidence Table

Structured evidence table for Lutein Supplementation Eye Strain Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Lutein Supplementation Eye Strain Randomized TrialThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Supplementation Eye Strain Randomized TrialEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Supplementation Eye Strain Randomized TrialTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Supplementation Eye Strain Randomized TrialBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.1Martinez-Perez C (2025)Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
Lutein Supplementation Eye Strain Randomized TrialMany clinical trials, including the Age-Related Eye Disease Study 1 and 2 (AREDS1 and AREDS2), have suggested that supplementation with retinal carotenoids reduces the risk of retinal diseases such as age-related macular degeneration (AMD) [,,,,].4Li Binxing (2025)Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
Lutein Supplementation Eye Strain Randomized Trial19 20 21 22 Genome-wide association studies (GWAS) have revealed that genetic variants of several HDL pathway proteins—such as ABCA1, SR-BI, LIPC, and CETP—are significantly associated with retinal carotenoid levels [,].4Li Binxing (2025)Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
Lutein Supplementation Eye Strain Randomized Trial23 24 25 26 Although retinal carotenoids are likely transported by HDL particles, they are also found in LDL particles in human serum [,].4Li Binxing (2025)Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
Lutein Supplementation Eye Strain Randomized Trial1 2 3 4 5 6 7 8 9 10 11 12 13 14 cis Carotenoids are natural antioxidants that can quench reactive oxygen species (ROS), thereby lowering oxidative stress and reducing inflammation [,,,].4Li Binxing (2025)Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
topicLutein Supplementation Eye Strain Randomized Trial
claimThis systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Supplementation Eye Strain Randomized Trial
claimEligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Supplementation Eye Strain Randomized Trial
claimTwo reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Supplementation Eye Strain Randomized Trial
claimBackground/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms.
evidence level1
citationMartinez-Perez C (2025)
sourceNutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
topicLutein Supplementation Eye Strain Randomized Trial
claimMany clinical trials, including the Age-Related Eye Disease Study 1 and 2 (AREDS1 and AREDS2), have suggested that supplementation with retinal carotenoids reduces the risk of retinal diseases such as age-related macular degeneration (AMD) [,,,,].
evidence level4
citationLi Binxing (2025)
sourceRetinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
topicLutein Supplementation Eye Strain Randomized Trial
claim19 20 21 22 Genome-wide association studies (GWAS) have revealed that genetic variants of several HDL pathway proteins—such as ABCA1, SR-BI, LIPC, and CETP—are significantly associated with retinal carotenoid levels [,].
evidence level4
citationLi Binxing (2025)
sourceRetinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
topicLutein Supplementation Eye Strain Randomized Trial
claim23 24 25 26 Although retinal carotenoids are likely transported by HDL particles, they are also found in LDL particles in human serum [,].
evidence level4
citationLi Binxing (2025)
sourceRetinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice
topicLutein Supplementation Eye Strain Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 13 14 cis Carotenoids are natural antioxidants that can quench reactive oxygen species (ROS), thereby lowering oxidative stress and reducing inflammation [,,,].
evidence level4
citationLi Binxing (2025)
sourceRetinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice

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Source documents

  1. Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
  2. Retinal Carotenoid Supplementation Increases HDL Cholesterol in Humans and Mice