topicLutein Supplementation Eye Health Randomized Trial
claimIntroduction The macula is a pigmented area located at the centre of the retina, responsible for central, high-resolution colour vision.
evidence level2
citationXu K (2026)
sourceEffect of carotenoids supplementation on visual function in Chinese adults free of retinal disease: protocol for the CSV double-blind, randomised, placebo-controlled trial.
topicLutein Supplementation Eye Health Randomized Trial
claimPrevious research has demonstrated that oral carotenoid supplementation can enhance contrast sensitivity (CS) in European populations.
evidence level2
citationXu K (2026)
sourceEffect of carotenoids supplementation on visual function in Chinese adults free of retinal disease: protocol for the CSV double-blind, randomised, placebo-controlled trial.
topicLutein Supplementation Eye Health Randomized Trial
claim7 9 The standard of care for many IRDs has largely focused on managing associated complications and the use of optical aids to improve quality of life.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Supplementation Eye Health Randomized Trial
claimThis review synthesizes both historical and contemporary evidence regarding dietary and nutritional interventions for IRDs.  14 Retinitis pigmentosa is one of the most common IRDs and is characterized by progressive photoreceptor cell death.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Supplementation Eye Health Randomized Trial
claimBy applying next-generation sequencing (NGS) technology to DNA samples stored from patients of the previous vitamin A trials, they were able to identify the specific RP gene variants for most participants and the lack of protective effect across genetic subtypes such as,and-associated retinitis pigmentosa [].
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease
topicLutein Supplementation Eye Health Randomized Trial
claim1 4 5 6 Inherited retinal diseases (IRDs) comprise a complex group of heterogenous disorders that lead to progressive retinal cell death and functional vision loss.
evidence level4
citationBarthelemy Normila (2026)
sourceNutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease