Lutein Supplementation Cognition Randomized Trial Evidence Table

Structured evidence table for Lutein Supplementation Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Lutein Supplementation Cognition Randomized TrialResults Compared to the placebo, lutein and zeaxanthin supplementation was associated with greater improvements in visual episodic memory ( p = 0.005) and visual learning ( p = 0.001).2Lopresti AL (2022)The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
Lutein Supplementation Cognition Randomized TrialConclusion The results from this trial suggest that 6-months of supplementation with lutein and zeaxanthin may improve visual memory and learning in community-dwelling adults with self-reported cognitive complaints.2Lopresti AL (2022)The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
Lutein Supplementation Cognition Randomized TrialBackground Lutein and zeaxanthin are fat-soluble, dietary carotenoids with high concentrations in human brain tissue.2Lopresti AL (2022)The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
Lutein Supplementation Cognition Randomized TrialThere have been a number studies confirming an association between lutein and zeaxanthin and cognitive function.2Lopresti AL (2022)The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
Lutein Supplementation Cognition Randomized TrialWhile the precise aetiology of AD remains unclear, ongoing research has yielded increasing evidence that disturbance of the biological processes associated with healthy brain ageing contribute to AD.3Ward Keanie (2025)Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
Lutein Supplementation Cognition Randomized TrialAge is the most prominent risk factor for AD, and it has been suggested that those aged 65 and over have a 1–2% risk, while those aged 85 and over have an 18–38% risk [,].3Ward Keanie (2025)Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
Lutein Supplementation Cognition Randomized TrialIt is crucial to differentiate pathological cognitive decline, observed in AD, from the cognitive changes associated with physiological ageing [].3Ward Keanie (2025)Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
Lutein Supplementation Cognition Randomized Trial1 2 3 4 5 6 7 Figure 1 8 9 10 7 11 12 13 14 15 Cognitive decline, whether age-related or indicative of neurodegenerative disorders such as dementia, is an escalating global health concern.3Ward Keanie (2025)Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
topicLutein Supplementation Cognition Randomized Trial
claimResults Compared to the placebo, lutein and zeaxanthin supplementation was associated with greater improvements in visual episodic memory ( p = 0.005) and visual learning ( p = 0.001).
evidence level2
citationLopresti AL (2022)
sourceThe Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
topicLutein Supplementation Cognition Randomized Trial
claimConclusion The results from this trial suggest that 6-months of supplementation with lutein and zeaxanthin may improve visual memory and learning in community-dwelling adults with self-reported cognitive complaints.
evidence level2
citationLopresti AL (2022)
sourceThe Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
topicLutein Supplementation Cognition Randomized Trial
claimBackground Lutein and zeaxanthin are fat-soluble, dietary carotenoids with high concentrations in human brain tissue.
evidence level2
citationLopresti AL (2022)
sourceThe Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
topicLutein Supplementation Cognition Randomized Trial
claimThere have been a number studies confirming an association between lutein and zeaxanthin and cognitive function.
evidence level2
citationLopresti AL (2022)
sourceThe Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
topicLutein Supplementation Cognition Randomized Trial
claimWhile the precise aetiology of AD remains unclear, ongoing research has yielded increasing evidence that disturbance of the biological processes associated with healthy brain ageing contribute to AD.
evidence level3
citationWard Keanie (2025)
sourceTherapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
topicLutein Supplementation Cognition Randomized Trial
claimAge is the most prominent risk factor for AD, and it has been suggested that those aged 65 and over have a 1–2% risk, while those aged 85 and over have an 18–38% risk [,].
evidence level3
citationWard Keanie (2025)
sourceTherapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
topicLutein Supplementation Cognition Randomized Trial
claimIt is crucial to differentiate pathological cognitive decline, observed in AD, from the cognitive changes associated with physiological ageing [].
evidence level3
citationWard Keanie (2025)
sourceTherapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
topicLutein Supplementation Cognition Randomized Trial
claim1 2 3 4 5 6 7 Figure 1 8 9 10 7 11 12 13 14 15 Cognitive decline, whether age-related or indicative of neurodegenerative disorders such as dementia, is an escalating global health concern.
evidence level3
citationWard Keanie (2025)
sourceTherapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease

Source documents

  1. The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.
  2. Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease