evidence table
Lutein Fatigue Randomized Trial Evidence Table
Structured evidence table for Lutein Fatigue Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Lutein Fatigue Randomized Trial | This systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue. | 1 | Martinez-Perez C (2025) | Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials. |
| Lutein Fatigue Randomized Trial | Eligible studies were RCTs involving individuals with myopia or at risk of myopia, comparing nutritional supplementation with placebo or active controls. | 1 | Martinez-Perez C (2025) | Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials. |
| Lutein Fatigue Randomized Trial | Two reviewers independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool. | 1 | Martinez-Perez C (2025) | Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials. |
| Lutein Fatigue Randomized Trial | Background/objectives Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms. | 1 | Martinez-Perez C (2025) | Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials. |
| Lutein Fatigue Randomized Trial | 7 9 The standard of care for many IRDs has largely focused on managing associated complications and the use of optical aids to improve quality of life. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Lutein Fatigue Randomized Trial | This review synthesizes both historical and contemporary evidence regarding dietary and nutritional interventions for IRDs.  14 Retinitis pigmentosa is one of the most common IRDs and is characterized by progressive photoreceptor cell death. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Lutein Fatigue Randomized Trial | By applying next-generation sequencing (NGS) technology to DNA samples stored from patients of the previous vitamin A trials, they were able to identify the specific RP gene variants for most participants and the lack of protective effect across genetic subtypes such as,and-associated retinitis pigmentosa []. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
| Lutein Fatigue Randomized Trial | 1 4 5 6 Inherited retinal diseases (IRDs) comprise a complex group of heterogenous disorders that lead to progressive retinal cell death and functional vision loss. | 4 | Barthelemy Normila (2026) | Nutritional supplements: current evidence for retinitis pigmentosa and Stargardt disease |
Source documents