topicLion'S Mane Cognitive Function Randomized Trial
claimAnother murine study found thatincreased levels of serotonin, dopamine, and noradrenaline, neurotransmitters that are often decreased in depression ().
evidence level2
citationSurendran Geyan (2025)
sourceAcute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
topicLion'S Mane Cognitive Function Randomized Trial
claim() found that 8 weeks ofsupplementation improved anxiety and depression measures in overweight or obese participants, also increasing circulating pro-BDNF levels.has also shown potential in improving cognitive functions in individuals with mild cognitive impairment.
evidence level2
citationSurendran Geyan (2025)
sourceAcute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
topicLion'S Mane Cognitive Function Randomized Trial
claim() found cognitive improvement after 16 weeks of 250 mg dailysupplementation in older adults.
evidence level2
citationSurendran Geyan (2025)
sourceAcute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
topicLion'S Mane Cognitive Function Randomized Trial
claim(Hericiaceae; Engl,: Lion’s Mane mushroom), is a toothed fungus endemic to the Northern Hemisphere.
evidence level2
citationSurendran Geyan (2025)
sourceAcute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study
topicLion'S Mane Cognitive Function Randomized Trial
claimFigure 1 Thus, in the present review we aimed to summarize the preclinical and clinical evidence of selected nutraceuticals, focusing on biotin, flavonoids especially luteolin, folic acid, Huperzine A, Lion’s mane, olive oil polyphenols (oleuropein and hydroxytyrosol [HT]), and palmitoylethanolamide (PEA).
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognitive Function Randomized Trial
claimThe present narrative review highlights current mechanistic insights, as well as evidence from experimental and clinical studies regarding their potential roles in supporting cognitive function, modulating neuroinflammation, and mitigating neurodegenerative processes.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognitive Function Randomized Trial
claimIt should be noted that the present work consists of a review and not a dosing guideline.
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience
topicLion'S Mane Cognitive Function Randomized Trial
claim1 1 Brain health is a multidimensional and evolving concept that is difficult to evaluate and quantify [].
evidence level3
citationVenetsanaki Vasiliki (2026)
sourceNatural Molecules for Brain Health and Resilience