topicLactoferrin Immune Randomized Trial
claimAs an integral component of the human diet, dairy products are rich in high-quality protein, lactoferrin, conjugated linoleic acid, calcium, vitamin D, and various other nutrients and bioactive compounds.
evidence level4
citationWang M (2026)
sourceA narrative review of nutritional components, health effects, and disease prevention mechanisms of dairy products.
topicLactoferrin Immune Randomized Trial
claimThey exert broad health benefits through core mechanisms involving multiple pathways and targets.
evidence level4
citationWang M (2026)
sourceA narrative review of nutritional components, health effects, and disease prevention mechanisms of dairy products.
topicLactoferrin Immune Randomized Trial
claimThe PICOS question was: 'Are lactoferrin levels different between individuals with periodontitis and periodontally healthy controls, and are these levels associated with disease severity and established clinical periodontal indicators, supporting their role as diagnostic or prognostic biomarkers for periodontitis?'.
evidence level4
citationPatil GV (2026)
sourceRole of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker.
topicLactoferrin Immune Randomized Trial
claimEgger's regression test produced a t-statistic of -0.646 (P=0.529), reflecting a lack of significant evidence for publication bias.
evidence level4
citationPatil GV (2026)
sourceRole of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker.
topicLactoferrin Immune Randomized Trial
claimIn conclusion, lactoferrin showed potential as a biomarker for periodontal disease, with elevated levels consistently linked to its presence and disease severity.
evidence level4
citationPatil GV (2026)
sourceRole of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker.
topicLactoferrin Immune Randomized Trial
claimThe present systematic review and meta-analysis assessed the clinical utility of lactoferrin as a biomarker for periodontitis by evaluating its association with established periodontal parameters, including probing pocket depth (PPD), clinical attachment loss (CAL) and gingival index (GI).
evidence level4
citationPatil GV (2026)
sourceRole of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker.