Structured evidence table for Lactoferrin Gut Barrier Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Lactoferrin Gut Barrier Randomized Trial | 11 12 11 13 14 15 16 17 18 19 Since the beginning of the COVID-19 crisis, public interest in hygiene, immunity, and inflammation has increased. | 3 | Lesgards Jean-François (2026) | Whey Proteins and Immunity: Mechanisms Underlying Immune System Reinforcement and Protection Against Viral and Bacterial Infections |
| Lactoferrin Gut Barrier Randomized Trial | Dairy intake, particularly low-fat products, has been associated with reduced COVID-19 severity and hospitalization [,]. | 3 | Lesgards Jean-François (2026) | Whey Proteins and Immunity: Mechanisms Underlying Immune System Reinforcement and Protection Against Viral and Bacterial Infections |
| Lactoferrin Gut Barrier Randomized Trial | More broadly, diets rich in fruits, vegetables, and omega-3s, and low in processed foods, may reduce inflammation and infection risk [,,], whereas malnutrition and obesity impair immunity and increase COVID-19 severity []. | 3 | Lesgards Jean-François (2026) | Whey Proteins and Immunity: Mechanisms Underlying Immune System Reinforcement and Protection Against Viral and Bacterial Infections |
| Lactoferrin Gut Barrier Randomized Trial | 1 The innate immune system provides rapid, nonspecific defense through barriers, cytokines, and cells such as macrophages, dendritic cells, and NK cells, while the adaptive system generates antigen-specific and long-lasting protection via T and B lymphocytes, forming an integrated network essential for host defense []. | 3 | Lesgards Jean-François (2026) | Whey Proteins and Immunity: Mechanisms Underlying Immune System Reinforcement and Protection Against Viral and Bacterial Infections |
| Lactoferrin Gut Barrier Randomized Trial | While advances in perinatal medicine and neonatal intensive care have significantly improved the survival rates of preterm infants, this progress has been accompanied by a rise in the incidence of NEC, with a global prevalence of approximately 7.0% among infants with extremely low birth weight (ELBW). | 3 | Chen Siyi (2026) | Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects |
| Lactoferrin Gut Barrier Randomized Trial | The precise etiology and pathogenesis of NEC remain incompletely understood; it is generally posited to be associated with multiple factors, such as intestinal barrier immaturity in preterm infants, gut microbiota dysbiosis, inappropriate feeding practices, and abnormal inflammatory responses (,). | 3 | Chen Siyi (2026) | Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects |
| Lactoferrin Gut Barrier Randomized Trial | These antimicrobial proteins, together with HMOs, support the establishment of a healthy microbiota, crucial for reducing the risk of NEC. | 3 | Chen Siyi (2026) | Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects |
| Lactoferrin Gut Barrier Randomized Trial | 1 2 3 4 5 6 Necrotizing enterocolitis (NEC) is a critical intestinal emergency that predominantly affects neonates, especially those born prematurely. | 3 | Chen Siyi (2026) | Synergistic regulation of gut microbiota and metabolites by breast milk and probiotics in the prevention of neonatal necrotizing enterocolitis: mechanisms and prospects |
| Lactoferrin Gut Barrier Randomized Trial | As an integral component of the human diet, dairy products are rich in high-quality protein, lactoferrin, conjugated linoleic acid, calcium, vitamin D, and various other nutrients and bioactive compounds. | 4 | Wang M (2026) | A narrative review of nutritional components, health effects, and disease prevention mechanisms of dairy products. |
| Lactoferrin Gut Barrier Randomized Trial | They exert broad health benefits through core mechanisms involving multiple pathways and targets. | 4 | Wang M (2026) | A narrative review of nutritional components, health effects, and disease prevention mechanisms of dairy products. |
Source documents