topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimFunctionally, ScEV-LrEVs showed enhanced anti-inflammatory activity in LPS-stimulated macrophages, accompanied by improved lysosomal function and coordinated changes in mTOR-TFEB-related lysosome-autophagy markers.
evidence level4
citationJi Z (2026)
sourceFungal extracellular vesicles reshape <i>Lactobacillus rhamnosus</i> vesicles to enhance lysosomal homeostasis and resolve intestinal inflammation.
topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimIn a DSS-induced colitis model, ScEV-LrEVs alleviated mucosal injury, reduced immune-cell infiltration, and reinforced epithelial barrier integrity, accompanied by restoration of lysosomal function and coordinated changes in mTOR-TFEB-related markers.
evidence level4
citationJi Z (2026)
sourceFungal extracellular vesicles reshape <i>Lactobacillus rhamnosus</i> vesicles to enhance lysosomal homeostasis and resolve intestinal inflammation.
topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimExtracellular vesicles (EVs) are emerging mediators of intercellular and interkingdom communication.
evidence level4
citationJi Z (2026)
sourceFungal extracellular vesicles reshape <i>Lactobacillus rhamnosus</i> vesicles to enhance lysosomal homeostasis and resolve intestinal inflammation.
topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimWhile bacterial EVs directly modulate host health, whether exogenous vesicles can reprogram gut microbial vesiculation and bioactivity remains unclear.
evidence level4
citationJi Z (2026)
sourceFungal extracellular vesicles reshape <i>Lactobacillus rhamnosus</i> vesicles to enhance lysosomal homeostasis and resolve intestinal inflammation.
topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimProbiotics are living microorganisms that improve overall human health by modulating the gut microbiota and enhancing absorption of nutrients and host immunity.
evidence level4
citationInamdar A (2026)
sourceUnveiling the probiotic potential of <i>L. rhamnosus</i> strain 044AE by genomic and phenotypic characterization.
topicLactobacillus Rhamnosus Gut Health Randomized Trial
claimDue to the growing demand for probiotics, efforts are being made to search for and characterize new probiotics.
evidence level4
citationInamdar A (2026)
sourceUnveiling the probiotic potential of <i>L. rhamnosus</i> strain 044AE by genomic and phenotypic characterization.