gut health

Lactobacillus Gut Barrier Randomized Trial Evidence Table

Structured evidence table for Lactobacillus Gut Barrier Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Lactobacillus Gut Barrier Randomized TrialNotably, GP restored colonic barrier integrity: GP potently upregulated the mRNA expression of tight junction proteins ZO-1 and occludin in the mechanical barrier and exhibited the most substantial restoration of both MUC2 and MUC4 expression levels in the mucins barrier, as well as reduced pro-inflammatory cytokines of TNF-α, IL-1β, IL-17 and elevated anti-inflammatory IL-10 in the immune barrier.4Li J (2026)The Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
Lactobacillus Gut Barrier Randomized TrialThe global prevalence of functional constipation has witnessed a marked increase due to the imbalanced dietary pattern.4Li J (2026)The Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
Lactobacillus Gut Barrier Randomized TrialThe prebiotic function in vitro and the anti-constipation efficacy of garlic polysaccharides (GP) in loperamide-induced constipated mice were evaluated.4Li J (2026)The Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
Lactobacillus Gut Barrier Randomized TrialIn a chronic Pb(II) exposure mouse model, GMNL-93 and GMNL-277 more effectively mitigated Pb(II)-associated liver damage, and upregulated RNA expression of gut function-associated proteins (e.g., Cldn3, Cldn5, and Muc5).4Chin YC (2026)Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
Lactobacillus Gut Barrier Randomized TrialMicrobiome and functional pathway analyses suggested strain-specific modes of action: GMNL-93 was associated with shifts in microbial composition and enrichment of pathways linked to redox balance and bile acid metabolism, whereas GMNL-277 was linked to enhanced thiamine-related metabolism; GMNL-32 showed comparatively limited protective.4Chin YC (2026)Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
Lactobacillus Gut Barrier Randomized TrialThis study explored the protective effects of lactobacilli against Pb(II)-induced hepatotoxicity in mice.4Chin YC (2026)Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
Lactobacillus Gut Barrier Randomized TrialThree strains of lactobacilli—Lacticaseibacillus paracasei GMNL-32, Limosilactobacillus fermentum GMNL-93, and Lacticaseibacillus casei GMNL-277—were evaluated for Pb adsorption and antioxidant activity.4Chin YC (2026)Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
topicLactobacillus Gut Barrier Randomized Trial
claimNotably, GP restored colonic barrier integrity: GP potently upregulated the mRNA expression of tight junction proteins ZO-1 and occludin in the mechanical barrier and exhibited the most substantial restoration of both MUC2 and MUC4 expression levels in the mucins barrier, as well as reduced pro-inflammatory cytokines of TNF-α, IL-1β, IL-17 and elevated anti-inflammatory IL-10 in the immune barrier.
evidence level4
citationLi J (2026)
sourceThe Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
topicLactobacillus Gut Barrier Randomized Trial
claimThe global prevalence of functional constipation has witnessed a marked increase due to the imbalanced dietary pattern.
evidence level4
citationLi J (2026)
sourceThe Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
topicLactobacillus Gut Barrier Randomized Trial
claimThe prebiotic function in vitro and the anti-constipation efficacy of garlic polysaccharides (GP) in loperamide-induced constipated mice were evaluated.
evidence level4
citationLi J (2026)
sourceThe Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
topicLactobacillus Gut Barrier Randomized Trial
claimIn a chronic Pb(II) exposure mouse model, GMNL-93 and GMNL-277 more effectively mitigated Pb(II)-associated liver damage, and upregulated RNA expression of gut function-associated proteins (e.g., Cldn3, Cldn5, and Muc5).
evidence level4
citationChin YC (2026)
sourceLactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
topicLactobacillus Gut Barrier Randomized Trial
claimMicrobiome and functional pathway analyses suggested strain-specific modes of action: GMNL-93 was associated with shifts in microbial composition and enrichment of pathways linked to redox balance and bile acid metabolism, whereas GMNL-277 was linked to enhanced thiamine-related metabolism; GMNL-32 showed comparatively limited protective.
evidence level4
citationChin YC (2026)
sourceLactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
topicLactobacillus Gut Barrier Randomized Trial
claimThis study explored the protective effects of lactobacilli against Pb(II)-induced hepatotoxicity in mice.
evidence level4
citationChin YC (2026)
sourceLactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.
topicLactobacillus Gut Barrier Randomized Trial
claimThree strains of lactobacilli—Lacticaseibacillus paracasei GMNL-32, Limosilactobacillus fermentum GMNL-93, and Lacticaseibacillus casei GMNL-277—were evaluated for Pb adsorption and antioxidant activity.
evidence level4
citationChin YC (2026)
sourceLactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.

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Source documents

  1. The Anti-Constipation Effect of Garlic Polysaccharides: Roles of Gut Barrier Integrity, VIP Pathway, and the Microbiota-SCFAs Axis.
  2. Lactobacillus protects against lead-induced hepatotoxicity by preserving the gut barrier and microbiota remodeling.