topicLactium Stress Randomized Trial
claimMicrobiome analysis revealed that the abundance of the genera Blautia and Ruminococcus increased in fecal samples from the LTC-022 group.
evidence level2
citationLim SE (2024)
sourceDietary supplementation with Lactium and L-theanine alleviates sleep disturbance in adults: a double-blind, randomized, placebo-controlled clinical study.
topicLactium Stress Randomized Trial
claimConclusion These results suggest that continuous LTC-022 intake has a beneficial effect on maintaining sleep duration and an appropriate bedtime.
evidence level2
citationLim SE (2024)
sourceDietary supplementation with Lactium and L-theanine alleviates sleep disturbance in adults: a double-blind, randomized, placebo-controlled clinical study.
topicLactium Stress Randomized Trial
claimIntroduction The use of natural products for the treatment of sleep disturbances is increasing owing to the side effects and limitations of traditional sleep therapy.
evidence level2
citationLim SE (2024)
sourceDietary supplementation with Lactium and L-theanine alleviates sleep disturbance in adults: a double-blind, randomized, placebo-controlled clinical study.
topicLactium Stress Randomized Trial
claimMoreover, recent studies have shown a significant correlation between sleep quality and gut microbiota composition.
evidence level2
citationLim SE (2024)
sourceDietary supplementation with Lactium and L-theanine alleviates sleep disturbance in adults: a double-blind, randomized, placebo-controlled clinical study.
topicLactium Stress Randomized Trial
claimFailure to meet the recommended 7-9 hours of restful sleep per night is known to increase the risk of several health conditions, reason why regular and adequate sleep should be seen as a priority instead of an unnecessary commodity easily traded as required by the commitments of our busy lives.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicLactium Stress Randomized Trial
claimWhile both the quantity and the quality of sleep can be largely improved with relatively straightforward practices dictated by good sleep hygiene, emerging research suggests that dietary and supplementation protocols focused on certain foods, nutrients, and biochemical compounds with sleep-promoting properties can act as subsidiary sleep aids in complementing these behavioral changes.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicLactium Stress Randomized Trial
claimThe scope of this narrative review is to summarize the available evidence on the potential benefits of selected nutraceuticals in the context of circadian rhythm and sleep disturbances, namely melatonin, magnesium, omega-3 fatty acids, tart cherry juice, kiwifruit, apigenin, valerian root, L-theanine, glycine, ashwagandha, myoinositol, Rhodiola rosea, and phosphatidylserine.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicLactium Stress Randomized Trial
claimHumans spend approximately one third of their life asleep but, as counterintuitive as it may sound, sleep is far from being a quiet state of inactivity.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.