topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimBackground Postmenopausal women are at increased risk of developing cardiovascular, muscular, and metabolic dysfunction due to hormonal changes associated with aging.
evidence level1
citationBahari H (2026)
sourceCitrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimConclusion Citrulline supplementation may offer benefits for blood pressure regulation (up to 9 mmHg SBP reduction in some studies) in hypertensive postmenopausal women, but evidence for arterial stiffness, endothelial function, and metabolic outcomes remains inconsistent.
evidence level1
citationBahari H (2026)
sourceCitrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimCitrulline, a non-essential amino acid and precursor to nitric oxide, has gained interest as a potential dietary supplement for improving vascular health, muscle function, and metabolic parameters in this population.
evidence level1
citationBahari H (2026)
sourceCitrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimThis review consolidates existing empirical evidence regarding the collective contributions of CIT, leucine, and physical exercise in fostering healthy aging, while also delineating prospective research avenues for the formulation of personalized nutritional and physical strategies aimed at enhancing both muscular and vascular well-being in the elderly population.
evidence level4
citationLin X (2026)
sourceTargeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention.
topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimAging is characterized by a gradual deterioration in skeletal muscle mass, strength, and vascular functionality, which ultimately leads to the development of sarcopenia and the subsequent loss of physical autonomy.
evidence level4
citationLin X (2026)
sourceTargeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention.
topicL-Citrulline Supplementation Postmenopausal Women Vascular Muscular Metabolic Effects
claimNutritional and exercise-based interventions that specifically address this interplay may offer viable, non-pharmacological approaches to maintaining both muscular and vascular integrity.
evidence level4
citationLin X (2026)
sourceTargeting muscle-vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention.