topicL-Citrulline Blood Flow Randomized Trial
claimBackground: Post-COVID-19 syndrome is associated with endothelial dysfunction (ED) and various sequelae, particularly in individuals who experienced critical illness during the acute phase, affecting lung function and the musculoskeletal system.
evidence level2
citationFernanda SM (2026)
sourceEffect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
topicL-Citrulline Blood Flow Randomized Trial
claimConclusions: L-citrulline supplementation for three months decreased ICAM-1 and increased 6MWT.
evidence level2
citationFernanda SM (2026)
sourceEffect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
topicL-Citrulline Blood Flow Randomized Trial
claimL-citrulline, a nonessential amino acid, has been shown to improve endothelial function, systemic inflammation, blood pressure, and physical performance.
evidence level2
citationFernanda SM (2026)
sourceEffect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomized Clinical Trial.
topicL-Citrulline Blood Flow Randomized Trial
claimData were analyzed using repeated-measures analysis of variance with appropriate post hoc adjustments, and statistical significance was set at P Results Compared with placebo, combined CITMAL + L-ARG supplementation significantly increased peak power output (747.85 ± 115.61 vs.
evidence level4
citationUçar H (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes.
topicL-Citrulline Blood Flow Randomized Trial
claim631.61 ± 108.40 W, P -1 , P P P -1 , P Conclusion The findings of this study indicate that combined L-ARG and CITMAL supplementation is associated with improvements in selected anaerobic performance, agility, and countermovement jump outcomes in highly trained taekwondo athletes.
evidence level4
citationUçar H (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes.
topicL-Citrulline Blood Flow Randomized Trial
claimPurpose This study aimed to examine the acute effects of citrulline malate (CITMAL), L-arginine (L-ARG), and their combined supplementation on anaerobic power output during a standardized Wingate test, as well as on post-exercise agility and countermovement jump performance in highly trained taekwondo athletes.
evidence level4
citationUçar H (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes.
topicL-Citrulline Blood Flow Randomized Trial
claimSixteen highly trained male taekwondo athletes ( ≥ 18 years) completed four experimental conditions- L-ARG (6 g), CITMAL (8 g), combined L-ARG + CITMAL, and placebo (PLA)-administered in powder form 1 h before exercise, with each trial separated by 72 h.
evidence level4
citationUçar H (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes.