evidence table
L-Arginine Cardiovascular Randomized Trial Evidence Table
Structured evidence table for L-Arginine Cardiovascular Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| L-Arginine Cardiovascular Randomized Trial | More importantly, this BP elevation was closely associated with adverse outcomes, with cardiovascular mortality risk increasing by 21% for every 10 mmHg increase in SBP, and winter cardiovascular mortality rates being 41% higher than those in summer (Yang et al. ). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Cardiovascular Randomized Trial | Given that cold environment‐induced BP elevation is one of the important modifiable risk factors for CVD (Gu et al. ; Yokoyama et al. ), targeted interventions to control elevated BP during cold weather are particularly crucial (Xu et al. ,). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Cardiovascular Randomized Trial | On the other hand, cold can upregulate L‐type calcium channels (Saad et al. ), induce oxidative stress (Briones and Touyz ; Martarelli et al. ), and impair endothelial NO bioavailability (Ding et al. ; Lanzinger, Breitner, et al. ), resulting in impaired vasodilatory function and increased BP. | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Cardiovascular Randomized Trial | BP CI CPT CVD DBP eNOS mmHg NO PICOS PRISMA PROSPERO RCT RoB 2 SBP WMD 2024 2025 2020 2020 2023 2017 2022 2024 2022 2017 2015 2023 2019 2024 2017 2015 2018 2014 2019 2024 2015 2020 Cardiovascular disease (CVD) represents the leading cause of the global disease burden (Chong et al. ; GBD 2021 ASEAN Cardiovascular Diseases Collaborators ; Roth et al. ). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Cardiovascular Randomized Trial | This is based on evidence from numerous randomized studies showing that treating patients with these BP values leads to benefits in the prevention and management of systemic diseases [,]. | 2 | Abate Federico (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine |
| L-Arginine Cardiovascular Randomized Trial | The continuous relationship between blood pressure and the risk of cardiovascular events has been demonstrated at all ages and across all ethnic groups and extends from high BP levels to relatively low values []. | 2 | Abate Federico (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine |
| L-Arginine Cardiovascular Randomized Trial | SBP becomes the dominant risk predictor with age, while diastolic elevations are more common in younger adults (<50 years) as DBP tends to change from middle age onward as a consequence of arterial stiffening []. | 2 | Abate Federico (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine |
| L-Arginine Cardiovascular Randomized Trial | 1 2 3 2 4 5 6 7 2 8 9 9 9 10 11 12 13 1 1 13 14 15 16 17 18 19 20 21 22 23 24 25 2+ 3+ − Hypertension is classified as stage 1 when the systolic pressure ranges from 130 to 139 mmHg or the diastolic pressure ranges from 80 to 89 mmHg. | 2 | Abate Federico (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine |
Source documents