evidence table
L-Arginine Blood Pressure Randomized Trial Evidence Table
Structured evidence table for L-Arginine Blood Pressure Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| L-Arginine Blood Pressure Randomized Trial | More importantly, this BP elevation was closely associated with adverse outcomes, with cardiovascular mortality risk increasing by 21% for every 10 mmHg increase in SBP, and winter cardiovascular mortality rates being 41% higher than those in summer (Yang et al. ). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Blood Pressure Randomized Trial | Given that cold environment‐induced BP elevation is one of the important modifiable risk factors for CVD (Gu et al. ; Yokoyama et al. ), targeted interventions to control elevated BP during cold weather are particularly crucial (Xu et al. ,). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Blood Pressure Randomized Trial | On the other hand, cold can upregulate L‐type calcium channels (Saad et al. ), induce oxidative stress (Briones and Touyz ; Martarelli et al. ), and impair endothelial NO bioavailability (Ding et al. ; Lanzinger, Breitner, et al. ), resulting in impaired vasodilatory function and increased BP. | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Blood Pressure Randomized Trial | BP CI CPT CVD DBP eNOS mmHg NO PICOS PRISMA PROSPERO RCT RoB 2 SBP WMD 2024 2025 2020 2020 2023 2017 2022 2024 2022 2017 2015 2023 2019 2024 2017 2015 2018 2014 2019 2024 2015 2020 Cardiovascular disease (CVD) represents the leading cause of the global disease burden (Chong et al. ; GBD 2021 ASEAN Cardiovascular Diseases Collaborators ; Roth et al. ). | 1 | Luo Ping (2026) | Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials |
| L-Arginine Blood Pressure Randomized Trial | Hypertension remains a major global health challenge, and pharmacological therapy is often constrained by tolerability issues. | 2 | Abate F (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine. |
| L-Arginine Blood Pressure Randomized Trial | Adjunctive approaches targeting the nitric oxide synthase and soluble guanylate cyclase-cyclic guanosine monophosphate (sGC-cGMP) pathway may offer additional benefits. | 2 | Abate F (2026) | A Nutraceutical Approach for Hypertension: Randomized Controlled Trial of Grape Pomace Extract and L-Arginine. |
Source documents