topicIron Exercise Performance Randomized Trial
claimIron's role in oxygen transport, mitochondrial respiration, and energy metabolism is central and even in the absence of anemia, low iron stores may greatly affect physical performance.Despite this, iron deficiency is frequently overlooked as a potential cause of unexplained fatigue, reduced exercise capacity, and presyncope, which complicates the diagnostic evaluation of athletes.
evidence level4
citationMcErlean Sarah M.E. (2026)
sourceNonanemic Iron Deficiency
topicIron Exercise Performance Randomized Trial
claimNew physiological evidence suggests that the cutoffs should be closer to 50 μg/L, as that is when the gastrointestinal tract begins to increase iron absorption.
evidence level4
citationMcErlean Sarah M.E. (2026)
sourceNonanemic Iron Deficiency
topicIron Exercise Performance Randomized Trial
claimThese higher thresholds are associated with improved aerobic performance and reduced exercise intolerance in women.
evidence level4
citationMcErlean Sarah M.E. (2026)
sourceNonanemic Iron Deficiency
topicIron Exercise Performance Randomized Trial
claimExercise intolerance is a common yet diagnostically challenging complaint in athletes.
evidence level4
citationMcErlean Sarah M.E. (2026)
sourceNonanemic Iron Deficiency