topicInulin Prebiotic Appetite Meta-Analysis
claimHowever, to our knowledge the literature thus far lacks a thorough discussion of the evidence from human clinical trials for the prebiotic effect of ITF, including beneficial effects on intestinal microbiota composition and intestinal and extraintestinal processes (e.g., glucose homeostasis, lipids, mineral absorption and bone health, appetite and satiety, inflammation and immune function, and body composition).
evidence level1
citationHughes RL (2022)
sourceThe Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.
topicInulin Prebiotic Appetite Meta-Analysis
claimEvidence from studies included in the current review suggest that ITF have a prebiotic effect on the intestinal microbiota, promoting the abundances of Bifidobacterium, Lactobacillus, and Faecalibacterium prausnitzii.
evidence level1
citationHughes RL (2022)
sourceThe Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.
topicInulin Prebiotic Appetite Meta-Analysis
claimBeneficial health effects reported following ITF intake include improved intestinal barrier function, improved laxation, increased insulin sensitivity, decreased triglycerides and an improved lipid profile, increased absorption of calcium and magnesium, and increased satiety.
evidence level1
citationHughes RL (2022)
sourceThe Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.
topicInulin Prebiotic Appetite Meta-Analysis
claimInulin-type fructans (ITF), including short-chain fructooligosaccharides (scFOS), oligofructose, and inulin, are commonly used fibers that are widely regarded as prebiotic for their ability to be selectively utilized by the intestinal microbiota to confer a health benefit.
evidence level1
citationHughes RL (2022)
sourceThe Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.
topicInulin Prebiotic Appetite Meta-Analysis
claimHowever, the response of PYY increased significantly after the control treatment with mean (sem) 11⋅1 (4⋅3) pg/ml when compared to the prebiotics -0⋅3 (4⋅3) pg/ml ( P = 0⋅013).
evidence level2
citationBirkeland E (2021)
sourceEffect of inulin-type fructans on appetite in patients with type 2 diabetes: a randomised controlled crossover trial.
topicInulin Prebiotic Appetite Meta-Analysis
claimThe aim of the study was to investigate the effect of prebiotic fibres on appetite-regulating hormones, subjective feeling of appetite and energy intake in subjects with type 2 diabetes.
evidence level2
citationBirkeland E (2021)
sourceEffect of inulin-type fructans on appetite in patients with type 2 diabetes: a randomised controlled crossover trial.
topicInulin Prebiotic Appetite Meta-Analysis
claimData presented are secondary outcomes of a study investigating the effect of prebiotics on glucagon-like peptide-1 and glycaemic regulation.
evidence level2
citationBirkeland E (2021)
sourceEffect of inulin-type fructans on appetite in patients with type 2 diabetes: a randomised controlled crossover trial.
topicInulin Prebiotic Appetite Meta-Analysis
claimBeyond these classical risk factors, gut microbiota dysbiosis is an established contributor to the pathogenesis of both disorders [].
evidence level3
citationBarakat Hassan (2026)
sourceProbiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management
topicInulin Prebiotic Appetite Meta-Analysis
claimIn particular, reduced microbial diversity and loss of beneficial taxa are associated with impaired intestinal barrier function, metabolic endotoxemia, chronic low-grade inflammation, and disrupted energy homeostasis, all of which favor insulin resistance and adiposity [,].
evidence level3
citationBarakat Hassan (2026)
sourceProbiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management
topicInulin Prebiotic Appetite Meta-Analysis
claimMicrobial imbalance has been consistently associated with reductions in SCFA-producing bacteria in studies of obesity and T2DM.
evidence level3
citationBarakat Hassan (2026)
sourceProbiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management
topicInulin Prebiotic Appetite Meta-Analysis
claim1 2 3 4 Obesity and T2DM are interrelated global epidemics caused by accelerated urbanization, dietary changes, sedentary lifestyles, and major disruptions to host metabolism [].
evidence level3
citationBarakat Hassan (2026)
sourceProbiotic Modulation of Gut Microbiota: Antioxidant Mechanisms and Clinical Benefits in Obesity and Type 2 Diabetes Management